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anti-Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) Antibodies

The protein encoded by SEL1L is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Additionally we are shipping SEL1L Proteins (4) and SEL1L Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SEL1L 6400 Q9UBV2
SEL1L 20338 Q9Z2G6
SEL1L 314352 Q80Z70
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Top anti-SEL1L Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB SEL1L Antibody (Center) (ABIN654642) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN263220 (1µg/ml) staining of HepG2 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Dog Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of MCF-7 cells using SEL1L Antibody (Center) Cat.-No AP53837PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human pancreas tissue stained with SEL1L antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SEL1L antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SEL1L Antibody (N-term) Cat.-No AP53838PU-N in T47D cell line lysates (35ug/lane). This demonstrates the SEL1L antibody detected the SEL1L protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB SEL1L Antibody (N-term)  western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the SEL1L antibody detected the SEL1L protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated IHC (fro), IHC (p), IP, WB Human Pancreas (formalin-fixed, paraffin-embedded) stained with SEL1L antibody ABIN334261 at 2.5-5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat pancreas labeled with Anti-SEL1L Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit APC FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

SEL1L Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SEL1L Antibodies

  1. Human Polyclonal SEL1L Primary Antibody for EIA, FACS - ABIN954711 : Cormier, Tamura, Sunryd, Hebert: EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. in Molecular cell 2009 (PubMed)
    Show all 4 references for ABIN954711

  2. Human Polyclonal SEL1L Primary Antibody for EIA, WB - ABIN954712 : Riemer, Appenzeller-Herzog, Johansson, Bodenmiller, Hartmann-Petersen, Ellgaard: A luminal flavoprotein in endoplasmic reticulum-associated degradation. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 4 references for ABIN954712

  3. Dog (Canine) Polyclonal SEL1L Primary Antibody for EIA, WB - ABIN374983 : Schelhaas, Malmström, Pelkmans, Haugstetter, Ellgaard, Grünewald, Helenius: Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. in Cell 2007 (PubMed)

More Antibodies against SEL1L Interaction Partners

Human Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. The SEL1L critically regulates HRD1 (show SYVN1 Antibodies)-mediated disposal of misfolded cargo through its short membrane spanning stretch.

  2. this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients

  3. Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma.

  4. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (show INS Antibodies) signalling to create a favourable micro-environment for ss-cell development and function.

  5. SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties.

  6. ATF6 (show ATF6 Antibodies) represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.

  7. ERdj5 (show DNAJC10 Antibodies), by binding to Sel1L, triggers BiP (show GDF10 Antibodies)-Cholera toxin interaction proximal to the Hrd1 (show SYVN1 Antibodies) complex; postulate this scenario enables the Hrd1 (show SYVN1 Antibodies)-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP (show GDF10 Antibodies)

  8. SEL1L expression is a potential colorectal cancer (CRC (show CALR Antibodies)) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC (show CALR Antibodies) cancers

  9. the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers.

  10. Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells.

Mouse (Murine) Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. Sel1L-Hrd1 (show SYVN1 Antibodies) plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease.

  2. Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein (show SYVN1 Antibodies) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  3. Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL (show LPL Antibodies) dimers from aggregation in the endoplasmic reticulum.

  4. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (show INS Antibodies) signalling to create a favourable micro-environment for ss-cell development and function.

  5. Sel1L is an indispensable component of the mammalian Hrd1 (show SYVN1 Antibodies) endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis.

  6. a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth

  7. an essential role for SEL1L in protein quality control during mouse embryonic development.

  8. Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development.

SEL1L Antigen Profile

Protein Summary

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SEL1L

  • Sel1-like (Nham_0248) antibody
  • Sel1-like (Nham_0743) antibody
  • Sel1-like (Nham_1053) antibody
  • Sel1-like (Nham_1754) antibody
  • hypothetical LOC281082 (LOC281082) antibody
  • sel-1 suppressor of lin-12-like (C. elegans) (SEL1L) antibody
  • sel-1 suppressor of lin-12-like (sel1l) antibody
  • sel-1 suppressor of lin-12-like (C. elegans) (Sel1l) antibody
  • AW493766 antibody
  • MGC99195 antibody
  • mKIAA4137 antibody
  • PRO1063 antibody
  • Sel-1L antibody
  • SEL1-LIKE antibody
  • Sel1h antibody
  • SEL1L antibody
  • SEL1L1 antibody

Protein level used designations for SEL1L

Sel1-like , hypothetical LOC281082 , sel-1 suppressor of lin-12-like (C. elegans) , sel-1 suppressor of lin-12-like , protein sel-1 homolog 1-like , Suppressor of lin 12 (sel-1), C. elegans, homolog of , protein sel-1 homolog 1 , sel-1 suppressor of lin-12-like 1 , suppressor of lin-12-like protein 1 , Sel1 (suppressor of lin-12) 1 homolog , sel-1L , Suppressor of lin-12-like protein 1

GENE ID SPECIES
4030996 Nitrobacter hamburgensis X14
4031503 Nitrobacter hamburgensis X14
4031659 Nitrobacter hamburgensis X14
4032796 Nitrobacter hamburgensis X14
281082 Bos taurus
423391 Gallus gallus
453080 Pan troglodytes
708651 Macaca mulatta
735099 Xenopus laevis
100052711 Equus caballus
100231514 Taeniopygia guttata
100353303 Oryctolagus cuniculus
100377925 Saccoglossus kowalevskii
100380038 Xenopus (Silurana) tropicalis
100408799 Callithrix jacchus
100477463 Ailuropoda melanoleuca
100548852 Meleagris gallopavo
100583688 Nomascus leucogenys
6400 Homo sapiens
480409 Canis lupus familiaris
100155424 Sus scrofa
614959 Bos taurus
20338 Mus musculus
314352 Rattus norvegicus
101834260 Mesocricetus auratus
Selected quality suppliers for anti-SEL1L (SEL1L) Antibodies
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