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The protein encoded by SEL1L is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Additionally we are shipping SEL1L Proteins (4) and SEL1L Kits (1) and many more products for this protein.
Showing 10 out of 71 products:
Human Polyclonal SEL1L Primary Antibody for EIA, FACS - ABIN954711
Cormier, Tamura, Sunryd, Hebert: EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. in Molecular cell 2009
Show all 4 references for ABIN954711
Human Polyclonal SEL1L Primary Antibody for EIA, WB - ABIN954712
Riemer, Appenzeller-Herzog, Johansson, Bodenmiller, Hartmann-Petersen, Ellgaard: A luminal flavoprotein in endoplasmic reticulum-associated degradation. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 4 references for ABIN954712
Dog (Canine) Polyclonal SEL1L Primary Antibody for EIA, WB - ABIN374983
Schelhaas, Malmström, Pelkmans, Haugstetter, Ellgaard, Grünewald, Helenius: Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. in Cell 2007
The SEL1L critically regulates HRD1 (show SYVN1 Antibodies)-mediated disposal of misfolded cargo through its short membrane spanning stretch.
this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients
Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma.
Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (show INS Antibodies) signalling to create a favourable micro-environment for ss-cell development and function.
SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties.
ATF6 (show ATF6 Antibodies) represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.
ERdj5 (show DNAJC10 Antibodies), by binding to Sel1L, triggers BiP (show GDF10 Antibodies)-Cholera toxin interaction proximal to the Hrd1 (show SYVN1 Antibodies) complex; postulate this scenario enables the Hrd1 (show SYVN1 Antibodies)-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP (show GDF10 Antibodies)
SEL1L expression is a potential colorectal cancer (CRC (show CALR Antibodies)) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC (show CALR Antibodies) cancers
the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers.
Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells.
Sel1L-Hrd1 (show SYVN1 Antibodies) plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease.
Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein (show SYVN1 Antibodies) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL (show LPL Antibodies) dimers from aggregation in the endoplasmic reticulum.
Sel1L is an indispensable component of the mammalian Hrd1 (show SYVN1 Antibodies) endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis.
a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth
an essential role for SEL1L in protein quality control during mouse embryonic development.
Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development.
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, hypothetical LOC281082
, sel-1 suppressor of lin-12-like (C. elegans)
, sel-1 suppressor of lin-12-like
, protein sel-1 homolog 1-like
, Suppressor of lin 12 (sel-1), C. elegans, homolog of
, protein sel-1 homolog 1
, sel-1 suppressor of lin-12-like 1
, suppressor of lin-12-like protein 1
, Sel1 (suppressor of lin-12) 1 homolog
, Suppressor of lin-12-like protein 1