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The protein encoded by THBS1 is a subunit of a disulfide-linked homotrimeric protein. Additionally we are shipping Thrombospondin 1 Kits (48) and Thrombospondin 1 Proteins (28) and many more products for this protein.
Showing 10 out of 168 products:
Cow (Bovine) Monoclonal Thrombospondin 1 Primary Antibody for Func, FACS - ABIN180505
Galvin, Dixit, ORourke, Santoro, Grant, Frazier: Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing. in The Journal of cell biology 1985
Show all 4 references for ABIN180505
Mammalian Monoclonal Thrombospondin 1 Primary Antibody for IF, IHC (p) - ABIN115006
Dixit, Haverstick, ORourke, Hennessy, Grant, Santoro, Frazier: Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. in Biochemistry 1985
Show all 3 references for ABIN115006
Human Polyclonal Thrombospondin 1 Primary Antibody for FACS, IF - ABIN652461
Hofsteenge, Huwiler, Macek, Hess, Lawler, Mosher, Peter-Katalinic: C-mannosylation and O-fucosylation of the thrombospondin type 1 module. in The Journal of biological chemistry 2001
Show all 3 references for ABIN652461
Cow (Bovine) Monoclonal Thrombospondin 1 Primary Antibody for FACS, IF - ABIN180348
Prater, Plotkin, Jaye, Frazier: The properdin-like type I repeats of human thrombospondin contain a cell attachment site. in The Journal of cell biology 1991
ELL (show ELL Antibodies) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
The anti-angiogenic activity of the native TSP-1 active fragment was maintained in the new TSP-1 mimetics and the results provide a new chemical approach for the design of TSP-1 mimetics.
In the current study Factor V Leiden (show F5 Antibodies), prothrombin (show F2 Antibodies) G20210A, and thrombospondin-1 polymorphisms showed no association with severity of hepatic fibrosis.
Triptolide can down regulates the expression of thrombospondin 1 and TGF-beta-1 (show TGFB1 Antibodies) in renal tubular cells. This plays a role in the pathogenesis of renal tubular fibrosis.
increased plasma thrombospondin-1 concentrations following ICH (show COL4a2 Antibodies) are independently associated with injury severity and short-term and long-term clinical outcomes
Novel role of TNFalpha (show TNF Antibodies) in inducing inflammatory stress response in human microvascular endothelial cells through Akt (show AKT1 Antibodies)- and P38 MAPK (show MAPK14 Antibodies)-mediated expression of TSP-1, independent of NFkappaB (show NFKB1 Antibodies) signaling.
Plasma thrombospondin-1 concentrations are elevated obviously and are highly associated with long-term outcome of ischemic stroke
TSP1 up regulation might be critically involved in the disease progression with rheumatoid arthritis.
The THBS1 N700S polymorphism was associated with coronary artery disease risk.
DLL4 (show DLL4 Antibodies)/Notch1 (show NOTCH1 Antibodies) and BMP9 (show GDF2 Antibodies) interdependent signaling induces endothelial cell quiescence via P27KIP1 (show CDKN1B Antibodies)/thrombospondin pathway.
Authors demonstrated that TSP-1 mRNA expression level was significantly upregulated in inflamed periodontitis gingival tissues
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 Antibodies) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 Antibodies), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 Antibodies)).
Thrombospondin has a role in inducing RhoA (show RHOA Antibodies) inactivation through FAK (show PTK2 Antibodies)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS Antibodies)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 Antibodies) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D Antibodies)).
Thrombospondin-1 was differentially expressed according to tumor grade, but not affected by p53 (show TP53 Antibodies) expression or mutational status
Data suggest neutrophil protease- Tsp-1 (thrombospondin-1) axis as a potential antimetastatic therapeutic target.
These results contribute new insights on the controversial role of TSP-1 (show GZMA Antibodies) in cancer.
TSP1 (show GZMA Antibodies) contributes to progression of chronic kidney disease by catalyzing activation of latent TGF-beta1 (show TGFB1 Antibodies), resulting in promotion of a fibroproliferative response over an inflammatory response.
Thrombospondin1 deficiency did not affect the development of obesity associated macro-vascular complication in ApoE (show APOE Antibodies)-/- mice, but attenuated obesity associated micro-vascular complications.
Thrombospondin-1 expression plays a significant role in regulation of migration and adhesion of mononuclear cells, contributing to vascular inflammation during AAA (show AAAS Antibodies) development.
findings prove that the TSP-1 (show GZMA Antibodies)/CD47 (show CD47 Antibodies)/SIRP (show SIRPA Antibodies)-alpha signal axis is important to the evolution of tumor cells in the microenvironment of immunotherapy and identify thrombospondin-1 as a key signal
ADAMTS-7 (show ADAMTS7 Antibodies) was directly associated with thrombospondin-1 by its C terminus and degraded thrombospondin-1 in vivo and in vitro. The inhibitory effect of ADAMTS-7 (show ADAMTS7 Antibodies) on postinjury endothelium recovery was circumvented in Tsp1 (show GZMA Antibodies)(-/-) mice.
Thrombospondin-1 and CD47 (show CD47 Antibodies) signaling regulate healing of thermal injury in mice.
Attenuation of thrombospondin-1-directed activation of TGF-beta1 (show TGFB1 Antibodies) promotes abdominal aortic aneurysm and atherosclerosis progression in the angiotensin II-infused ApoE (show APOE Antibodies)(-/-) mouse model.
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 Antibodies) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 Antibodies) expression.
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, cancer/testis antigen 36
, glyceraldehyde-3-phosphate dehydrogenase-like 5
, testis specific protein 1 (probe H4-1 p3-1)
, testis-specific protein TPX-1