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anti-Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C) Antibodies

USH1C encodes a scaffold protein that functions in the assembly of Usher protein complexes. Additionally we are shipping Usher Syndrome 1C (Autosomal Recessive, Severe) Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USH1C 72088 Q9ES64
USH1C 308596  
USH1C 10083 Q9Y6N9
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Top anti-Usher Syndrome 1C (Autosomal Recessive, Severe) Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB USH1C Antibody (N-term) (ABIN1881984) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the USH1C antibody detected the USH1C protein (arrow). USH1C Antibody (N-term) (ABIN1881984) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the USH1C antibody detected the USH1C protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185190 (0.1 ug/ml) staining of HEK293 lysate (35 ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. ABIN185190 (10 ug/ml) staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. (Data have been obtained with ABIN185190 from a previous batch). 100 μg Log in to see 4 to 5 Days
$318.20
Details
Cow Goat Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IP, IHC (p), ELISA, WB Immunochemical staining of human USH1C in human colon-carcinoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium. The left panel: tissue incubated with primary antibody; Th Immunochemical staining of human USH1C in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Log in to see 16 Days
$218.90
Details
Human Goat Un-conjugated IHC (p), ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged USH1C is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged USH1C is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (37.84 KDa) . 100 μg Log in to see 9 Days
$430.00
Details

USH1C Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Human ,
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Top referenced anti-Usher Syndrome 1C (Autosomal Recessive, Severe) Antibodies

  1. Human Polyclonal USH1C Primary Antibody for WB - ABIN1881984 : Yan, Pan, Chen, Wu, Zhang: The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 4 references for ABIN1881984

  2. Human Polyclonal USH1C Primary Antibody for IHC, ELISA - ABIN185190 : Verpy, Leibovici, Zwaenepoel, Liu, Gal, Salem, Mansour, Blanchard, Kobayashi, Keats, Slim, Petit: A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C. in Nature genetics 2000 (PubMed)

More Antibodies against Usher Syndrome 1C (Autosomal Recessive, Severe) Interaction Partners

Mouse (Murine) Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C) interaction partners

  1. Harmonin enhances voltage-dependent facilitation of Cav1.3 (show CACNA1D Antibodies) channels and synchronous exocytosis in mouse inner hair cells.

  2. MYO7A (show MYO7A Antibodies), USH1G (Sans) and CDH23 (show CDH23 Antibodies) form the upper tip-link complex in adult mice, likely in combination with USH1C (harmonin).

  3. examine the effects of null mutation of the Ush1c gene on subcellular localization of Myo7a, Pcdh15 and Sans in the inner ear

  4. Cadherin-23 (show CDH23 Antibodies), myosin VIIa (show MYO7A Antibodies) and harmonin form a ternary complex and interact with phospholipids.

  5. The fact that Ush1c expression is much higher in the ear than in the eye suggests a different role for Ush1c in ear function than in the eye and may explain why Ush1c mutant mice do not recapitulate vision defects.

  6. forms a complex with cadherin 23 (show CDH23 Antibodies) by means of PDZ-domain (show INADL Antibodies) interactions

  7. the shaping of the hair bundle relies on a functional unit composed of myosin VIIa (show MYO7A Antibodies), harmonin b and cadherin 23 (show CDH23 Antibodies) that is essential to ensure the cohesion of the stereocilia

  8. Harp (show C5orf13 Antibodies) + harmonin constitute a scaffolding complex to facilitate signal transduction in epithelia.

  9. Rac-DOCK4-actin-binding protein harmonin-activated signaling pathway is possibly involved in regulating actin cytoskeleton organization in stereocilia of the inner ear.

  10. harmonin is a upper tip-link density component and contributes to establishing the sensitivity of mechanotransduction channels to displacement.

Human Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C) interaction partners

  1. Mutations of USHIC can cause both Usher syndrome type IC and nonsyndromic recessive deafness DFNB18.

  2. ANKS4B, and MYO7B (show MYO7B Antibodies) form a stable ternary complex for anchoring microvilli tip-link cadherins

  3. harmonin and villin autoantibodies are sensitive and specific markers of IPEX (show FOXP3 Antibodies), differentiate IPEX (show FOXP3 Antibodies), including atypical cases, from other early childhood disorders associated with enteropathy

  4. We localized proteins encoded by the top two regulated genes, TBL1X (show TBL1X Antibodies) and USH1C, using immunohistochemistry to placental stem and anchoring villi associated with active contractile function.

  5. Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia

  6. Pathogenic mutations in MYO7A, USH1C, and USH1G have been found in four consanguineous Israeli Arab families with Usher syndrome type 1.

  7. We report a novel molecular cause of sector retinitis pigmentosa associated with hearing loss representing a new phenotype associated with mutations in the USH1C gene.

  8. Mutations in USH1C are responsible for 1.5% of Usher syndrome type I disease in patients of Spanish origin.

  9. Mutations in harmonin and Sans found in USH1 patients are shown to destabilize the complex formation of the two proteins

  10. USH1C 216G-->A mutation and the 9-repeat VNTR(t,t) allele are in complete linkage disequilibrium in the Acadian population

Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C) Antigen Profile

Protein Summary

This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with USH1C

  • harmonin (CpipJ_CPIJ012732) antibody
  • harmonin (LOC100345203) antibody
  • Usher syndrome 1C (Ush1c) antibody
  • Usher syndrome 1C (autosomal recessive, severe) (USH1C) antibody
  • 2010016F01Rik antibody
  • AIE-75 antibody
  • DFNB18 antibody
  • DFNB18A antibody
  • harmonin antibody
  • NY-CO-37 antibody
  • NY-CO-38 antibody
  • PDZ-45 antibody
  • PDZ-73 antibody
  • PDZ-73/NY-CO-38 antibody
  • PDZ73 antibody
  • PDZD7C antibody
  • ush1cpst antibody

Protein level used designations for USH1C

harmonin , PDZ domain-containing protein , Usher syndrome 1C homolog , usher syndrome type-1C protein homolog , harmonin a1 , antigen NY-CO-38/NY-CO-37 , autoimmune enteropathy-related antigen AIE-75 , renal carcinoma antigen NY-REN-3 , usher syndrome type-1C protein

GENE ID SPECIES
6045741 Culex quinquefasciatus
100345203 Oryctolagus cuniculus
72088 Mus musculus
308596 Rattus norvegicus
10083 Homo sapiens
530709 Bos taurus
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