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anti-beta-Site APP-Cleaving Enzyme 1 (BACE) Antibodies

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Kits (58) and beta-Site APP-Cleaving Enzyme 1 Proteins (33) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817
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Top anti-beta-Site APP-Cleaving Enzyme 1 Antibodies at antibodies-online.com

Showing 10 out of 240 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-BACE1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Log in to see 3 to 7 Days
$269.50
Details

BACE Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-beta-Site APP-Cleaving Enzyme 1 Antibodies

  1. Human Polyclonal BACE Primary Antibody for EIA, IHC (p) - ABIN358083 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for ABIN358083

  2. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201 : He, Li, Chang, Tang: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for ABIN392201

  3. Human Polyclonal BACE Primary Antibody for WB - ABIN264995 : Hussain, Powell, Howlett, Tew, Meek, Chapman, Gloger, Murphy, Southan, Ryan, Smith, Simmons, Walsh, Dingwall, Christie: Identification of a novel aspartic protease (Asp 2) as beta-secretase. in Molecular and cellular neurosciences 2000 (PubMed)
    Show all 4 references for ABIN264995

  4. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN401041 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 4 references for ABIN401041

  5. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN389517 : Huang, Chang, Koelsch, Turner, Lupu, Tang: Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN389517

  6. Human Polyclonal BACE Primary Antibody for WB - ABIN392200 : Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN392200

  7. Human Polyclonal BACE Primary Antibody for IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)

  8. Chicken Polyclonal BACE Primary Antibody for IHC, WB - ABIN2782766 : Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. in Molecular and cellular biology 2008 (PubMed)

More Antibodies against beta-Site APP-Cleaving Enzyme 1 Interaction Partners

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. The electrophysiological effects of BACE1 on KCNQ1 (show KCNQ1 Antibodies) reported here were independent of its enzymatic activity.

  2. Results suggest that ubiquilin-1 (show UBQLN1 Antibodies) may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP (show APP Antibodies) processing and Abeta (show APP Antibodies) accumulation

  3. Results indicate that DISC (show DISC1 Antibodies)1 attenuates Abeta generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysoso (show APP Antibodies)mal degradation of BACE1

  4. A single bout of exercise reduced BACE1 cortical content and activity in obese mice.

  5. reduction in miR (show MLXIP Antibodies)-186 levels during aging may lead to the up-regulation of BACE1 in the brain, thereby increasing a risk for Alzheimer's disease

  6. reveal Dicer1 (show DICER1 Antibodies)-miR (show MLXIP Antibodies)-328-Bace1 signalling as a determinant of brown adipose tissue function

  7. The present findings are consistent with our previous behavioral data showing that BACE1 haploinsufficiency rescues memory deficits in 5XFAD mice irrespective of sex but only in the younger age group.

  8. p38alpha (show MAPK14 Antibodies) MAPK (show MAPK1 Antibodies) plays a critical role in the regulation of BACE1 degradation and Abeta (show APP Antibodies) generation in Alzheimer Disease pathogenesis

  9. Swedish mutant APP (show APP Antibodies)-based BACE1 binding site peptide reduces APP (show APP Antibodies) beta-cleavage and cerebral Abeta (show APP Antibodies) levels in Alzheimer's mice.

  10. evidence that HFD, by regulation of subcellular trafficking of BACE1, promotes APP (show APP Antibodies) cleavage.

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Results suggest that ubiquilin-1 (show UBQLN1 Antibodies) may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP (show APP Antibodies) processing and Abeta (show APP Antibodies) accumulation

  2. Results suggest that DISC1 (show DISC1 Antibodies) interacts with BACE1 and promotes lysosomal degradation of BACE1, thus reducing the generation of Abeta (show APP Antibodies)

  3. GG genotype and G allele of BACE1 gene rs638405 probably increase the risk of AD. [META-ANALYSIS]

  4. study reports that sAbetaPPalpha, the product of the cleavage of AbetaPP by alpha-secretase, is a potent endogenous direct inhibitor of the BACE enzyme, and that its inhibition is likely by an allosteric mechanism

  5. p38alpha (show MAPK14 Antibodies) MAPK (show MAPK1 Antibodies) plays a critical role in the regulation of BACE1 degradation and Abeta (show APP Antibodies) generation in Alzheimer Disease pathogenesis

  6. this is the first study to acquire a DNA aptamer that exhibited binding specificity to BACE1 and inhibited its activity.

  7. Results reveal a link between p25 (show LCN2 Antibodies) and BACE1 in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 (show CDK5 Antibodies) activation by p25 (show LCN2 Antibodies) accelerates AD pathogenesis by enhancing BACE1 activity via phosphorylation.

  8. the Alzheimer's disease-protective 'Icelandic' mutation greatly attenuates APP (show APP Antibodies)-BACE-1 interactions, suggesting a mechanistic basis for protection.

  9. Studies suggest that beta-Secretases BACE1/2 plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure.

  10. analysis of the differential dose-dependent effects of simvastatin on HIF-1alpha (show HIF1A Antibodies) and BACE in cultured Alzheimer's disease cybrid cells

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 Antibodies) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen Profile

Protein Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-site APP-cleaving enzyme 1 (BACE1) antibody
  • beta-site APP-cleaving enzyme 1 (MGC145931) antibody
  • beta-site APP-cleaving enzyme 1 (LOC100232107) antibody
  • beta-site APP-cleaving enzyme 2 (bace2) antibody
  • beta-site APP-cleaving enzyme 2 (BACE2) antibody
  • beta-site APP-cleaving enzyme 2 (LOC100224177) antibody
  • beta-site APP cleaving enzyme 1 (Bace1) antibody
  • beta-site APP-cleaving enzyme 1 (bace1) antibody
  • ASP2 antibody
  • BACE antibody
  • BACE1 antibody
  • BACE2 antibody
  • C76936 antibody
  • HSPC104 antibody
  • MGC68482 antibody
  • MGC68881 antibody
  • MGC145931 antibody
  • zgc:77409 antibody

Protein level used designations for BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPECIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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