Sad1 and UNC84 Domain Containing 1 (SUN1) antibody

Antigen: Sad1 and UNC84 Domain Containing 1 (SUN1)

Synonyms: UNC84A, FLJ12407, KIAA0810, MGC176649

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Catalog no.: ABIN1042680

Additional Information

Alternative name: SUN1

Immunogen: GST-Sun 1 peptide

Format: Liquid

Description: Synonyms: Protein unc-84 homolog A antibody,Sad1/unc 84 protein like 1 antibody,Sad1/unc-84 protein-like 1 antibody,Sun domain-containing protein 1 antibody,Sun1 antibody,SUN1_HUMAN antibody,UNC 84 homolog A (C elegans) antibody,UNC 84A antibody,UNC84 A antibody,UNC84 antibodyNC84 homolog A (C elegans) antibody

Specificity: Human SUN1

Comments:

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs)

Application Details

Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline try between 1:500-1:2000

Purification: Serum

Research Area: Chromatin and Nuclear Signaling, Cell Cycle

Restrictions: For Research Use only

Images

anti-Sad1 and UNC84 Domain Containing 1 (SUN1) antibody

Publications

Product: Hodzic, Yeater, Bengtsson et al.: "Sun2 is a novel mammalian inner nuclear membrane protein." in: The Journal of biological chemistry, Vol. 279, Issue 24, pp. 25805-12, 2004 (PubMed).