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anti-CEACAM6 (CEA-related cell adhesion molecule 5, non-specific cross-reacting antigen (NCA), CD66c) antibody

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Image for anti-CEACAM6 (CEA-related cell adhesion molecule 5, non-specific cross-reacting antigen (NCA), CD66c) antibody
Antigen: CEACAM6 (CEA-related cell adhesion molecule 5, non-specific cross-reacting antigen (NCA), CD66c)
Clonality: Monoclonal (9A6)
Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Cell-ELISA (cELISA), Western Blotting (WB), ELISA
Reactivity: Human
Host: Mouse
12 references available 12 references available
Quantity: 100 ug (1mg/ml)
Price: 551,31 $   (Plus shipping costs $25 and VAT, Invoice in EUR)
Order number: ABIN108733
Availability: Ships within 1 to 2 Business days
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Additional Information  » anti-CEACAM6 (CEA-related cell adhesion molecule 5, non-specific cross-reacting antigen (NCA), CD66c) antibody

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Antigen CEACAM6 (CEA-related cell adhesion molecule 5, non-specific cross-reacting antigen (NCA), CD66c)
Swiss-Prot P40199
Immunogen Immunisation with tumor cell lines expressing CEACAM6
Reactivity Human
Clonality Monoclonal
Format Purified
Isotype IgG1 »Matching secondary antibodies
Description CEA-related cell adhesion molecule 6 (CEACAM6, NCA) belongs to the carcinoembryonic antigen (CEA) gene family (13). It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a Mr of 90,000 which is strongly expressed on epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes (Fig. 2, Ref. 4, 10). CEACAM6 expression is upregulated in many adenocarcinomas (4) and leukemias (5). Like all members of the CEA family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constant-like A and B domain.
Clone 9A6
Host Mouse
Specificity Anti-human CEACAM6 (NCA, CD66c)

Application Details  » anti-CEACAM6 (CEA-related cell adhesion molecule 5, non-specific cross-reacting antigen (NCA), CD66c) antibody

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Application Flow Cytometry (FACS), Immunohistochemistry (IHC), Cell-ELISA (cELISA), Western Blotting (WB), ELISA
» Click here to view 9 available protocols!
Application Notes 26/5/1 has been tested for the use in flow cytometry (1.2 ug/10^6 cells), cell-ELISA (1:200), ELISA (1:200 - 1:400), Western blots (4ug/ml) and immunohistology on cryosections (1-2 ug/10^6 cells).
Concentration 1mg/ml
Purification Protein G
Buffer Phosphate buffered saline, pH 7.2
Storage Short term: 2°C - 8°C. Long term: -20°C (avoid repeated freezing and thawing)
Research Area Receptors, Immunology, Cancer, Receptors, Cell/Tissue Markers, Cancer
Restrictions For Research Use only

Publications  » anti-CEACAM6 (CEA-related cell adhesion molecule 5, non-specific cross-reacting antigen (NCA), CD66c) antibody

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Publications Gottlinger HG, Lobo FM, Grimm TW et al.: "Biochemical characterization and tissue distribution of the Cora antigen, a cell surface glycoprotein differentially expressed on malignant and benign gastrointestinal epithelia." In: Cancer Res , Vol. 48, Issue 8, pp. 2198-203, 1988 (PubMed)

Daniel S, Nagel G, Johnson JP et al.: "Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants." In: Int J Cancer , Vol. 55, Issue 2, pp. 303-10, 1993 (PubMed)

Thompson, Moessinger, Reichardt et al.: "A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members." In: International journal of cancer. Journal international du cancer , Vol. 55, Issue 2, pp. 311-9, 1993 (PubMed)

Krop-Watorek, Laskowska, Salwa et al.: "CEA-related proteins on human urothelial cell lines of different transformation grades." In: Cancer letters , Vol. 139, Issue 1, pp. 15-22, 1999 (PubMed)

Schoelzel, Zimmermann, Schwarzkopf et al.: "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas." In: The American journal of pathology , Vol. 156, Issue 2, pp. 595-605, 2000 (PubMed)

Muenzner, Dehio, Fujiwara et al.: "Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells." In: Infection and immunity , Vol. 68, Issue 6, pp. 3601-7, 2000 (PubMed)

Muenzner P, Naumann M, Meyer TF et al.: "Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1, previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear facto" In: J Biol Chem , Vol. 276, Issue 26, pp. 24331-40, 2001 (PubMed)

Watt SM, Teixeira AM, Zhou GQ et al.: "Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site." In: Blood , Vol. 98, Issue 5, pp. 1469-79, 2001 (PubMed)

Kilic, Oliveira-Ferrer, Neshat-Vahid et al.: "Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1." In: Blood , Vol. 110, Issue 13, pp. 4223-33, 2007 (PubMed)

Suemiramoth, Gleizes, Turbica et al.: "Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism." In: Journal of leukocyte biology , Vol. 85, Issue 2, pp. 310-21, 2009 (PubMed)

Carvalho, Barnich, Sivignon et al.: "Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM." In: The Journal of experimental medicine , Vol. 206, Issue 10, pp. 2179-89, 2009 (PubMed)

Rolhion, Barnich, Bringer et al.: "Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion." In: Gut , 2010 (PubMed)