CEACAM1/5 antibody

Catalog No. ABIN108735

Product Details anti-CEACAM1/5 Antibody

Target: CEACAM1/5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1/5 (CEACAM1/5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CEACAM1/5 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Cell-ELISA (cELISA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Anti-human CEACAM1, 5 (BGP, CEA, CD66a,e)

Purification: Protein G

Immunogen: immunisation with extracted protein of CEACAM5

Clone: 4-3-17

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 Western blot: 4 µg/mL
Immunohistology: 1-2 µg/10^6 cells (on cryosections)
For each application a titration should be performed to determine the optimal concentration.

Comment:

Synonyms: CD66ae, BGP, CEA

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

Target Details for CEACAM1/5

Target: CEACAM1/5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1/5 (CEACAM1/5))

Alternative Name: CEACAM1,5 (CEACAM1/5 Products)

Synonyms: CD66e antibody, CEA antibody, carcinoembryonic antigen related cell adhesion molecule 5 antibody, CEACAM5 antibody

Background: Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

UniProt: P06731, P13688