PAX5 antibody (AA 235-382)

Catalog No. ABIN1098104

The Mouse Monoclonal anti-PAX5 antibody has been validated for ELISA and IHC. It is suitable to detect PAX5 in samples from Human. There are 2+ publications available.

Quick Overview for PAX5 antibody (AA 235-382) (ABIN1098104)

Target: PAX5 (Paired Box 5 (PAX5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 7D3

Product Details anti-PAX5 Antibody

Binding Specificity: AA 235-382

Purpose: PAX5 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PAX5 antibody (ABIN1098104)

OBrien, Morin, Ouellette, Robichaud: "The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease." in: Cancer research, Vol. 71, Issue 24, pp. 7345-50, (2011) (PubMed).

Nasr, Rosenthal, Syrbu: "Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker." in: American journal of clinical pathology, Vol. 133, Issue 1, pp. 41-8, (2009) (PubMed).

Target Details for PAX5

Target: PAX5 (Paired Box 5 (PAX5))

Alternative Name: PAX5

Background: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Molecular Weight: 45 kDa

UniProt: Q02548