TNFRSF1B antibody (FITC)

Catalog No. ABIN1105817

The Mouse Monoclonal anti-TNFRSF1B antibody has been validated for IP, FACS, IF, Func and EIA. It is suitable to detect TNFRSF1B in samples from Human and Rat. There is 1 publication available.

Quick Overview for TNFRSF1B antibody (FITC) (ABIN1105817)

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF1B antibody is conjugated to FITC

Application: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: 80M2

Product Details anti-TNFRSF1B Antibody (FITC)

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 1 % bovine serum

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

References for anti-TNFRSF1B antibody (FITC) (ABIN1105817)

Krippner-Heidenreich, Grunwald, Zimmermann, Kühnle, Gerspach, Sterns, Shnyder, Gill, Männel, Pfizenmaier, Scheurich: "Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8176-83, (2008) (PubMed).

Target Details for TNFRSF1B

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Alternative Name: CD120b / TNFR2

Background: TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNF-RII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha.Synonyms: TNF-R2, TNFBR, TNFRSF1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor type II, p80 TNF-alpha receptor

Gene ID: 9606

UniProt: P20333

Pathways: NF-kappaB Signaling, Apoptosis, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway