Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody

Details for Product No. ABIN110595
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Antigen
Synonyms
CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr, lap3, lcr1, lestr, npy3r, npyr, npyrl, npyy3r, whim, xcxcr4, cxcr4, CD184, Cmkar4, LESTR, PB-CKR, PBSF/SDF-1, Sdf1r, D2S201E, FB22, HM89, HSY3RR, LA ... show more
CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr, lap3, lcr1, lestr, npy3r, npyr, npyrl, npyy3r, whim, xcxcr4, cxcr4, CD184, Cmkar4, LESTR, PB-CKR, PBSF/SDF-1, Sdf1r, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, CXC-R4-B, CXCR-4-B, CXCR4, cb403, zgc:109863 show less
Reactivity
Rat (Rattus), Mouse (Murine)
(219), (111), (65), (29), (14), (12), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(179), (40), (20), (13), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS), Neutralization (Neut)
(162), (77), (76), (60), (38), (29), (29), (27), (20), (8), (7), (5), (4), (1), (1), (1)
Pubmed 5 references available
Quantity 0.2 mg
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
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Catalog No. ABIN110595
214.50 $
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Immunogen This polyclonal antibody, which reacts with both rat and mouse CXCR4, was generated using E. coli-expressed rat CXCR4 as an immunogen.
Specificity Cross-reactivity to CXCR4 of other species has not been determined.
Alternative Name CXCR4
Background CXCR4 (fusin) is one of the members in the seven-transmembrane G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library1. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been proved to be the co-receptor for HIV?s binding to CD4 through envelope glycoprotein gp 1202. In other cases, CXCR4 can even function as the only receptor for HIV-2?s binding to the CD4 ? host cells3. Mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
Research Area Chemokines, Receptors
Application Notes The tested titer for Western blot is 1:2,000
Restrictions For Research Use only
Format Lyophilized
Storage 4 °C
Supplier Images
anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody
General Petit, Szyper-Kravitz, Nagler et al.: "G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4." in: Nature immunology, Vol. 3, Issue 7, pp. 687-94, 2002 (PubMed).

Shyu, Lin, Yang et al.: "Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells." in: Circulation, Vol. 110, Issue 13, pp. 1847-54, 2004 (PubMed).

Neusser, Lindenmeyer, Moll et al.: "Human nephrosclerosis triggers a hypoxia-related glomerulopathy." in: The American journal of pathology, Vol. 176, Issue 2, pp. 594-607, 2010 (PubMed).

Chen, Chemaly, Liang et al.: "Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1705-15, 2010 (PubMed).

Kioi, Vogel, Schultz et al.: "Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice." in: The Journal of clinical investigation, Vol. 120, Issue 3, pp. 694-705, 2010 (PubMed).

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