Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody

Antigen: Chemokine (C-X-C Motif) Receptor 4 (CXCR4)

Synonyms: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, MGC108696, CXCR4, MGC128682, cxcr4, cxcr4-B, CXC-R4-B, CXCR-4-B, MGC52882, MGC130802, fb22, hm89, lap3, lcr1, npyr, whim, cd184, lestr, npy3r, npyrl, CXC-R4, CXCR-4, hsy3rr, npyy3r, xcxcr4, d2s201e

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus), Mouse (Murine)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Neutralization (Neut)

Catalog no.: ABIN110595

Additional Information

Alternative name: CXCR4

Immunogen: This polyclonal antibody, which reacts with both rat and mouse CXCR4, was generated using E. coli-expressed rat CXCR4 as an immunogen.

Format: Protein A purified, 0.1% sodium azide, Lyophilized

Description: CXCR4 (fusin) is one of the members in the seven-transmembrane G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library1. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been proved to be the co-receptor for HIV?s binding to CD4 through envelope glycoprotein gp 1202. In other cases, CXCR4 can even function as the only receptor for HIV-2?s binding to the CD4 ? host cells3. Mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.

Specificity: Cross-reactivity to CXCR4 of other species has not been determined.

Synonyms: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, MGC108696, CXCR4, MGC128682, cxcr4, cxcr4-B, CXC-R4-B, CXCR-4-B, MGC52882, MGC130802, fb22, hm89, lap3, lcr1, npyr, whim, cd184, lestr, npy3r, npyrl, CXC-R4, CXCR-4, hsy3rr, npyy3r, xcxcr4, d2s201e

Application Details

Application Notes: The tested titer for Western blot is 1:2,000

Storage: 4 C for short term storage or -20 C in small aliquots for long term storage. Avoid repeated freeze and thaw. Reconstitute to 1 mg/ml by adding 200 µ l H2O

Research Area: Chemokines, Receptors

Restrictions: For Research Use only

Images

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody

Publications

Petit, Szyper-Kravitz, Nagler et al.: "G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4." in: Nature immunology, Vol. 3, Issue 7, pp. 687-94, 2002 (PubMed).

Shyu, Lin, Yang et al.: "Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells." in: Circulation, Vol. 110, Issue 13, pp. 1847-54, 2004 (PubMed).

Neusser, Lindenmeyer, Moll et al.: "Human nephrosclerosis triggers a hypoxia-related glomerulopathy." in: The American journal of pathology, Vol. 176, Issue 2, pp. 594-607, 2010 (PubMed).

Chen, Chemaly, Liang et al.: "Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1705-15, 2010 (PubMed).

Kioi, Vogel, Schultz et al.: "Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice." in: The Journal of clinical investigation, Vol. 120, Issue 3, pp. 694-705, 2010 (PubMed).