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CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4)

Details for Product anti-CXCR4 Antibody No. ABIN110595, Supplier: Login to see
Antigen
  • CXC-R4
  • CXCR-4
  • cd184
  • d2s201e
  • fb22
  • hm89
  • hsy3rr
  • lap3
  • lcr1
  • lestr
  • npy3r
  • npyr
  • npyrl
  • npyy3r
  • whim
  • xcxcr4
  • cxcr4
  • CD184
  • Cmkar4
  • LESTR
  • PB-CKR
  • PBSF/SDF-1
  • Sdf1r
  • D2S201E
  • FB22
  • HM89
  • HSY3RR
  • LAP3
  • LCR1
  • NPY3R
  • NPYR
  • NPYRL
  • NPYY3R
  • WHIM
  • CXC-R4-B
  • CXCR-4-B
  • CXCR4
  • cb403
  • zgc:109863
Reactivity
Rat (Rattus), Mouse (Murine)
307
137
73
13
5
4
4
4
3
2
2
2
2
1
1
1
1
Host
Rabbit
221
77
34
31
3
Clonality
Polyclonal
Conjugate
This CXCR4 antibody is un-conjugated
15
9
7
6
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
222
119
99
73
68
40
32
21
14
13
9
8
7
6
3
2
2
2
2
2
1
1
1
1
Supplier
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Immunogen This polyclonal antibody, which reacts with both rat and mouse CXCR4, was generated using E. coli-expressed rat CXCR4 as an immunogen.
Specificity Cross-reactivity to CXCR4 of other species has not been determined.
Alternative Name CXCR4 (CXCR4 Antibody Abstract)
Background CXCR4 (fusin) is one of the members in the seven-transmembrane G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library1. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been proved to be the co-receptor for HIV?s binding to CD4 through envelope glycoprotein gp 1202. In other cases, CXCR4 can even function as the only receptor for HIV-2?s binding to the CD4 ? host cells3. Mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
Research Area Chemokines, Receptors
Pathways
Application Notes The tested titer for Western blot is 1:2,000
Restrictions For Research Use only
Format Lyophilized
Storage 4 °C
Supplier Images
 image for anti-CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (ABIN110595) anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody
Product cited in: Kioi, Vogel, Schultz et al.: "Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice." in: The Journal of clinical investigation, Vol. 120, Issue 3, pp. 694-705, 2010 (PubMed).

Chen, Chemaly, Liang et al.: "Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1705-15, 2010 (PubMed).

Neusser, Lindenmeyer, Moll et al.: "Human nephrosclerosis triggers a hypoxia-related glomerulopathy." in: The American journal of pathology, Vol. 176, Issue 2, pp. 594-607, 2010 (PubMed).

Shyu, Lin, Yang et al.: "Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells." in: Circulation, Vol. 110, Issue 13, pp. 1847-54, 2004 (PubMed).

Petit, Szyper-Kravitz, Nagler et al.: "G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4." in: Nature immunology, Vol. 3, Issue 7, pp. 687-94, 2002 (PubMed).