TRIM13 antibody (Middle Region)

Catalog No. ABIN1109332

This Rabbit Polyclonal antibody specifically detects TRIM13 in WB and IHC (p). It exhibits reactivity toward Human, Mouse, Rat and Cow.

Quick Overview for TRIM13 antibody (Middle Region) (ABIN1109332)

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Reactivity: Human, Mouse, Rat, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TRIM13 Antibody

Binding Specificity: Middle Region

Sequence: DTLETSKRKS LQLLTKDSDK VKEFFEKLQH TLDQKKNEIL SDFETMKLAV

Cross-Reactivity (Details): Species reactivity (expected):Rat, Mouse, BovineSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TRIIM13 antibody: synthetic peptide directed towards the middle region of human TRIM13

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TRIM13

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Alternative Name: TRIM13 / RNF77

Background: TRIM13 is an E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. TRIM13 enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, regulates ER stress-induced autophagy, and may act as a tumor suppressor.Synonyms: B-cell chronic lymphocytic leukemia tumor suppressor Leu5, LEU5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RFP2, RING finger protein 77, Tripartite motif-containing protein 13

Gene ID: 10206

NCBI Accession: NP_005789