Keratin 17 (KRT17) antibody

Details for Product No. ABIN114619
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Antigen
Synonyms PC, K17, PC2, PCHC1, Krt1-17, Ka17, si:dkeyp-113d7.7, KRT17, krt16
Reactivity
Human, Rat (Rattus)
(133), (78), (54), (13), (13), (1), (1), (1)
Host
Mouse
(88), (62), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(111), (77), (46), (43), (35), (29), (27), (20), (9), (4), (4), (1)
Pubmed 8 references available
Catalog no. ABIN114619
Quantity 0.1 mg
Price
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Immunogen A cytoskeletal preparation from rat colon
Clone Ks17-E3
Isotype IgG2b
Specificity Clone E3 reacts with cytokeratin 17 in basal layers of pseudo-stratified and transitional epithelia.
Purification Purified
Alternative Name Cytokeratin 17
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immuno-histochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Alternate names: CK17, Cytokeratin-17, K17, KRT17, Keratin 17, Keratin type I cytoskeletal 17, Keratin-17
Gene ID 3872
NCBI Accession NP_000413.1
UniProt Q04695
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Immunoblotting (1: 100 - 1: 1000). Immunocytochemistry. Immunohistochemistry on frozen and paraffin-embedded tissues (1: 25- 1: 200 forimmunohistochemistry with avidin-biotinylated horseradish peroxidase complec (ABC) asdetection regant). Flow cytometry (1: 25-1: 200)Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 50% glycerol, 0.1% BSA and 0.02 % sodium azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Smedts, Ramaekers, Troyanovsky et al.: "Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia." in: The American journal of pathology, Vol. 140, Issue 3, pp. 601-12, 1992 (PubMed).

Wetzels, Schaafsma, Leigh et al.: "Laminin and type VII collagen distribution in different types of human lung carcinoma: correlation with expression of keratins 14, 16, 17 and 18." in: Histopathology, Vol. 20, Issue 4, pp. 295-303, 1992 (PubMed).

Smedts, Ramaekers, Troyanovsky et al.: "Keratin expression in cervical cancer." in: The American journal of pathology, Vol. 141, Issue 2, pp. 497-511, 1992 (PubMed).

Wetzels, Kuijpers, Lane et al.: "Basal cell-specific and hyperproliferation-related keratins in human breast cancer." in: The American journal of pathology, Vol. 138, Issue 3, pp. 751-63, 1991 (PubMed).

Guelstein, Tchypysheva, Ermilova et al.: "Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer." in: International journal of cancer. Journal international du cancer, Vol. 42, Issue 2, pp. 147-53, 1988 (PubMed).

Troyanovsky, Guelstein, Tchipysheva et al.: "Patterns of expression of keratin 17 in human epithelia: dependency on cell position." in: Journal of cell science, Vol. 93 ( Pt 3), pp. 419-26, 1990 (PubMed).

Smedts, Ramaekers, Link et al.: "Detection of keratin subtypes in routinely processed cervical tissue: implications for tumour classification and the study of cervix cancer aetiology." in: Virchows Archiv : an international journal of pathology, Vol. 425, Issue 2, pp. 145-55, 1994 (PubMed).

Litvinov, van Driel, van Rhijn et al.: "Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation." in: The American journal of pathology, Vol. 148, Issue 3, pp. 865-75, 1997 (PubMed).

Hosts (88), (62), (4)
Reactivities (133), (78), (54), (13), (13), (1), (1), (1)
Applications (111), (77), (46), (43), (35), (29), (27), (20), (9), (4), (4), (1)
Conjugates (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (12), (4), (2), (2), (1), (1)
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