Thymidine Phosphorylase antibody

Catalog No. ABIN114827

Product Details anti-Thymidine Phosphorylase Antibody

Target: Thymidine Phosphorylase (TYMP)

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thymidine Phosphorylase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody is specific to a 55 kDa protein known as Platelet-Derived Endothelial Growth Factor (PD-ECGF), similar to thymidine phosphorylase (TP). Cellular localization: Cytoplasmic, Nuclear.

Purification: Purified

Immunogen: A recombinant full length human thymidine phophorylase (TP/PD-ECGF) protein.

Clone: P-GF-44C

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use a dilution of1/25-1/75 in an ABC method (30 minutes at room temperature). Western blotting: 1/50-1/100. Recommended Positive Control: Breast carcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Thymidine Phosphorylase

Target: Thymidine Phosphorylase (TYMP)

Abstract: TYMP Products

Synonyms: ECGF antibody, ECGF1 antibody, MEDPS1 antibody, MNGIE antibody, MTDPS1 antibody, PDECGF antibody, TP antibody, hPD-ECGF antibody, 2900072D10Rik antibody, Ecgf1 antibody, PD-ECGF antibody, Pdgfec antibody, typh antibody, thymidine phosphorylase antibody, thymidine phosphorylase DeoA antibody, AMP phosphorylase antibody, Thymidine phosphorylase antibody, TYMP antibody, Tymp antibody, deoA antibody, Dd586_0614 antibody, Kvar_4413 antibody, NMAG_RS19330 antibody, Snov_1187 antibody, Fbal_2856 antibody, Ftrac_2071 antibody, Intca_1216 antibody, ARCVE_RS10415 antibody, Sphch_4174 antibody, Sinme_3461 antibody, METOK_RS06355 antibody, Mesop_1831 antibody, typh antibody

Background: Platelet - derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites. High levels of TP/PD-ECGF are observed in cancer patients. High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.Synonyms: ECGF1, Gliostatin, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase

Gene ID: 1890

NCBI Accession: NP_001107227

UniProt: P19971

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2