Angiostatin (ANG) antibody

Antigen: Angiostatin (ANG)

Synonyms: DKFZp779M0222, Pg, AI649309, Ab1-346, PLG, LPA, wu:fb70e09, plg, DKFZp470G2422

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN115500

Additional Information

Characteristics: Synonyms: Plasminogen, PLG

Alternative name: Angiostatin

Swiss-Prot: P00747

Description: Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis,which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumorgrowth and can maintain metastatic and primary tumors in a dormant state. It is defined bya balance of proliferation and apoptosis of the tumor cells and is composed ofplasminogen first four cringle structures. This molecule is generated by proteolyticcleavage of plasminogen. Recombinant angiostatin has 260 amino acids, residues 97-357of human proplasminogen, and a calculated molecular mass of 29. 8 kDa.

Specificity: The antibody was raised in rabbits by immunization with the Human Angiostatin fromhuman plasma. Species: Human. Others not tested.

Application Details

Application Notes: ELISA. Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Buffer: 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREEReconstitution: Restore with 0.1 ml of deionized water

Storage: Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time, it does not showdecline in activity after two weeks at 4°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Cancer, Angiogenesis, Cytokines

Restrictions: For Research Use only