CIITA antibody (N-Term)

Catalog No. ABIN116527

This Rabbit Polyclonal antibody specifically detects CIITA in WB, IP and EIA. It exhibits reactivity toward Human.

Quick Overview for CIITA antibody (N-Term) (ABIN116527)

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIITA antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Product Details anti-CIITA Antibody

Binding Specificity: AA 1-333, N-Term

Sequence: Peptide: IKDNKELPQY LALTTR

Purification: This product was prepared from monospecific antiserum by delipidation and defibrination.

Immunogen: Peptide corresponding to a region near the N-terminal end of the human CIITA gene conjugated to Keyhole Limpet Hemocyanin (KLH).

Application Details

Application Notes: Suitable for Immunoblotting (1/500), ELISA and Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 90.0 mg/mL (by Refractometry)

Handling Advice: Avoid repeated freezing or thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store original vial at 2-8 °C. After reconstitution store stock solution at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for CIITA

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Alternative Name: CIITA / C2TA

Background: The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.Synonyms: MHC class II transactivator, MHC2TA

Gene ID: 4261

NCBI Accession: NP_000237

UniProt: P33076

Pathways: Cancer Immune Checkpoints