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Integrin, alpha 6 (ITGA6) antibody (FITC)

Details for Product No. ABIN118232
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Antigen
Synonyms inta6, ITGA6, im:6897425, itga6, si:dkey-32o22.1, wu:fb80g02, LOC100221694, 5033401O05Rik, AI115430, Cd49f, VLA-6, CD49f, ITGA6B
Reactivity
Dog (Canine), Human, Monkey, Mouse (Murine), Pig (Porcine), Sheep (Ovine)
(154), (47), (20), (14), (12), (9), (9), (9), (1)
Host
Rat
(65), (57), (51), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(17), (11), (11), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(97), (76), (48), (37), (32), (29), (19), (16), (12), (10), (6), (3), (2), (2)
Pubmed 9 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN118232
423.50 $
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Immunogen BALB/c mouse mammary tumour cells. Spleen cells from immunised Sprague-Dawley rats were fused with cells of the SP2/0 mouse myeloma cell line.
Clone NKI-GoH3
Isotype IgG2a
Specificity This antibody recognises CD49F (VLA-6 alpha chain). Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts. VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone GoH3 specifically blocks the binding of cells to the E8 fragment of laminin.
Purification Affinity chromatography on Protein G
Alternative Name CD49f / ITGA6
Background CD49f is a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells.
Alternate names: CD49 antigen-like family member F, Integrin alpha-6, VLA-6, VLA6
Gene ID 3655
NCBI Accession NP_000201.2
UniProt P23229
Application Notes Flow cytometry: Use 10 ul of neat antibody to label 10e6 cells in 100 ul. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Integrin, alpha 6 (ITGA6) antibody (FITC) Staining of human peripheral blood lymphocytes with Rat anti Human/Mouse CD49f-FITC (ABIN118232).
Background publications Sonnenberg, Hogervorst, Osterop et al.: "Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic." in: The Journal of biological chemistry, Vol. 263, Issue 28, pp. 14030-8, 1988 (PubMed).

Hemler, Crouse, Takada et al.: "Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures." in: The Journal of biological chemistry, Vol. 263, Issue 16, pp. 7660-5, 1988 (PubMed).

Sonnenberg, Modderman, Hogervorst: "Laminin receptor on platelets is the integrin VLA-6." in: Nature, Vol. 336, Issue 6198, pp. 487-9, 1989 (PubMed).

Sonnenberg, Janssen, Hogervorst et al.: "A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody." in: The Journal of biological chemistry, Vol. 262, Issue 21, pp. 10376-83, 1987 (PubMed).

Galkowska, Waldemar, Wojewodzka: "Reactivity of antibodies directed against human antigens with surface markers on canine leukocytes." in: Veterinary immunology and immunopathology, Vol. 53, Issue 3-4, pp. 329-34, 1997 (PubMed).

Yoshino, Ami, Terao et al.: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

Ding, Xu, Da Ros et al.: "On-chip two-mode division multiplexing using tapered directional coupler-based mode multiplexer and demultiplexer." in: Optics express, Vol. 21, Issue 8, pp. 10376-82, 2013 (PubMed).

General Sonnenberg, Linders, Modderman et al.: "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8." in: The Journal of cell biology, Vol. 110, Issue 6, pp. 2145-55, 1990 (PubMed).

Sonnenberg, Daams, Van der Valk et al.: "Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 34, Issue 8, pp. 1037-46, 1986 (PubMed).

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