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Integrin, alpha 6 (ITGA6) antibody

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Synonyms inta6, ITGA6, im:6897425, itga6, si:dkey-32o22.1, wu:fb80g02, LOC100221694, 5033401O05Rik, AI115430, Cd49f, VLA-6, CD49f, ITGA6B
Dog (Canine), Human, Monkey, Mouse (Murine), Pig (Porcine)
(274), (95), (35), (17), (16), (11), (8), (6), (2), (2), (2), (2), (1), (1), (1)
(105), (100), (99), (2)
Clonality (Clone)
Monoclonal ()
(40), (32), (19), (5), (5), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
(183), (104), (74), (51), (46), (41), (28), (19), (11), (8), (7), (7), (5), (3), (2), (2), (2), (1)
Pubmed 10 references available
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Quantity 0.2 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen BALB/c mouse mammary tumour cells. Spleen cells from immunised Sprague-Dawley rats were fused with cells of the SP2/0 mouse myeloma cell line.
Clone NKI-GoH3
Isotype IgG2a
Specificity The monoclonal antibody is directed against the CDw49f-antigen. This monoclonal NKI-GoH3 antibody reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytiotrophoblasts. Platelet VLA-6 functions as a laminin receptor and platelet adhesion to laminin is inhibited by GoH3. Studies suggest that Clone NKI-GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (See Sonnenberg, A. et al. for details).
Purification Affinity Chromatography on Protein G
Alternative Name CD49f / ITGA6 (ITGA6 Antibody Abstract)
Background CDw49f-antigen is a 120kD, (GP Ic or VLA-6 alpha-chain), which can form distinct complexes with either the CD29-antigen (GP 11a or VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells.Synonyms: CD49 antigen-like family member F, Integrin alpha-6, VLA-6, VLA6
Gene ID 3655
NCBI Accession NP_000201
UniProt P23229
Application Notes Flow cytometry. Immunohistochemistry on frozen sections. Recommended positive control: Human Tonsil. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Integrin, alpha 6 (ITGA6) antibody (ABIN118233) Staining of human peripheral blood lymphocytes with RAT ANTI HUMAN/MOUSE CD49f
Background publications Ding, Xu, Da Ros et al.: "On-chip two-mode division multiplexing using tapered directional coupler-based mode multiplexer and demultiplexer." in: Optics express, Vol. 21, Issue 8, pp. 10376-82, 2013 (PubMed).

Ferreri, Illerhaus, Zucca et al.: "Flows and flaws in primary central nervous system lymphoma." in: Nature reviews. Clinical oncology, Vol. 7, Issue 8, pp. doi:10.1038/nrclinonc.2010.9-c1; author reply doi:10:1038/nrclinonc.2010.9-c2, 2010 (PubMed).

Jensen, Driskell, Watt: "Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis." in: Nature protocols, Vol. 5, Issue 5, pp. 898-911, 2010 (PubMed).

Galkowska, Waldemar, Wojewodzka: "Reactivity of antibodies directed against human antigens with surface markers on canine leukocytes." in: Veterinary immunology and immunopathology, Vol. 53, Issue 3-4, pp. 329-34, 1997 (PubMed).

Sonnenberg, Janssen, Hogervorst et al.: "A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody." in: The Journal of biological chemistry, Vol. 262, Issue 21, pp. 10376-83, 1987 (PubMed).

Sonnenberg, Modderman, Hogervorst: "Laminin receptor on platelets is the integrin VLA-6." in: Nature, Vol. 336, Issue 6198, pp. 487-9, 1989 (PubMed).

Hemler, Crouse, Takada et al.: "Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures." in: The Journal of biological chemistry, Vol. 263, Issue 16, pp. 7660-5, 1988 (PubMed).

Hemler, Crouse, Sonnenberg: "Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines." in: The Journal of biological chemistry, Vol. 264, Issue 11, pp. 6529-35, 1989 (PubMed).

Sonnenberg, Hogervorst, Osterop et al.: "Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic." in: The Journal of biological chemistry, Vol. 263, Issue 28, pp. 14030-8, 1988 (PubMed).

Sonnenberg, Daams, Van der Valk et al.: "Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 34, Issue 8, pp. 1037-46, 1986 (PubMed).

Catalog No. ABIN118233
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