Integrin alpha 1 (ITGA1) antibody

Details for Product No. ABIN118693
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Antigen
Synonyms CD49A, E130012M19Rik, Vla1, CD49a, VLA1
Reactivity
Human
(70), (24), (24), (12), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(43), (31), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (7), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Flow Cytometry (FACS)
(40), (25), (25), (18), (14), (13), (10), (8), (7), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.2 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN118693
588.50 $
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Clone TS2-7
Isotype IgG1
Specificity This antibody recognises the alpha 1 integrin sub-unit, which forms the VLA-1 heterodimer in association with the beta 1 integrin.
Purification Affinity Chromatography on Protein G
Alternative Name CD49a / ITGA1
Background VLA-1 is a receptor for collagen and laminin, and is expressed by chronically activated T cells, melanoma cells and smooth muscle cells.
Alternate names: CD49 antigen-like family member A, ITGA-1, Integrin alpha-1, Laminin and Collagen Receptor, VLA-1, VLA1
Gene ID 3672
NCBI Accession NP_852478
UniProt P56199
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 10 ul of 1/25-1/50 diluted antibody to label 10e6 cells in 100 ul. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Integrin alpha 1 (ITGA1) antibody Staining of HeLa cells with MOUSE ANTI HUMAN CD49a (ABIN118693).
Background publications Hemler, Sanchez-Madrid, Flotte et al.: "Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 132, Issue 6, pp. 3011-8, 1984 (PubMed).

General Hemler, Jacobson, Strominger: "Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells." in: The Journal of biological chemistry, Vol. 260, Issue 28, pp. 15246-52, 1986 (PubMed).

Hafler, Hemler, Christenson et al.: "Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases." in: Clinical immunology and immunopathology, Vol. 37, Issue 2, pp. 163-71, 1985 (PubMed).

Validation Images
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