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CD51 antibody

ITGAV Reactivity: Human, Chicken FACS, IP Host: Mouse Monoclonal 23C6 unconjugated
Catalog No. ABIN118723
  • Target See all CD51 (ITGAV) Antibodies
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    Reactivity
    • 93
    • 50
    • 24
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Chicken
    Host
    • 67
    • 27
    • 6
    Mouse
    Clonality
    • 57
    • 42
    Monoclonal
    Conjugate
    • 52
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD51 antibody is un-conjugated
    Application
    • 50
    • 43
    • 28
    • 25
    • 18
    • 14
    • 14
    • 12
    • 11
    • 9
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    Purification
    Affinity Chromatography on Protein A.
    Immunogen
    Osteoclasts from osteoclastomas. Spleen cells from immunised mice were fused with cells of the mouse X63.Ag8.653 myeloma cell line.
    Clone
    23C6
    Isotype
    IgG1
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    Discover our top product ITGAV Primary Antibody
  • Application Notes
    Flow Cytometry: Use 10 μL of 1/40-1/80 diluted antibody to label 10^6 cells in 100 μL. Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4, containing 0.09 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    Alternative Name
    CD51 / ITGAV (ITGAV Products)
    Synonyms
    1110004F14Rik antibody, 2610028E01Rik antibody, CD51 antibody, D430040G12Rik antibody, MSK8 antibody, VNRA antibody, VTNR antibody, Cd51 antibody, integrin subunit alpha V antibody, integrin alpha V antibody, ITGAV antibody, Itgav antibody
    Background
    CD51/CD61 is an integrin complex known as alphaV beta3. It is expressed at high levels on osteoclasts, endothelial cells, and melanoma cells and at low levels on platelets and macrophages. CD51 is a heterodimer composed of disulfide-linked 125 kD and 24 kD proteins. CD61 is also a member of the integrin family known as gpIIIa or beta3 integrin. It is a 110 kD common beta subunit of CD51/CD61 or CD41/CD61 complex. CD51/CD61, also known as the vitronectin receptor, mediates the binding of platelets to immobilized vitronectin without prior activation. Other ligands include RGD-containing proteins such as fibrinogen, fibronectin, von Willebrand factor (vWf), laminin, thrombospondin and the neural adhesion molecule L1. CD51/CD61 also mediates cell-cell adhesion via interaction with CD31. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components.Synonyms: CD51, CD61, GP3A, GPIIIa, ITGAV, ITGB-3, ITGB3, Integrin alpha-V, Integrin beta-3, MSK8, Platelet membrane glycoprotein IIIa, VNRA, Vitronectin Receptor, Vitronectin receptor subunit alpha
    Gene ID
    9606
    UniProt
    P06756
    Pathways
    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex
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