Integrin alpha V (ITGAV) antibody

Details for Product No. ABIN118723
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Antigen
Synonyms 1110004F14Rik, 2610028E01Rik, CD51, D430040G12Rik, MSK8, VNRA, VTNR, Cd51
Reactivity
Chicken, Human
(151), (74), (32), (26), (26), (26), (21)
Host
Mouse
(88), (63), (39), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(24), (15), (14), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Flow Cytometry (FACS), Immunoprecipitation (IP)
(134), (58), (54), (36), (26), (24), (20), (19), (19), (17), (9), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN118723
253.00 $
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Immunogen Osteoclasts from osteoclastomas. Spleen cells from immunised mice were fused with cells of the mouse X63.Ag8.653 myeloma cell line.
Clone 23C6
Isotype IgG1
Purification Affinity Chromatography on Protein A.
Alternative Name CD51 / ITGAV
Background CD51/CD61 is an integrin complex known as alphaV beta3. It is expressed at high levels on osteoclasts, endothelial cells, and melanoma cells and at low levels on platelets and macrophages. CD51 is a heterodimer composed of disulfide-linked 125 kD and 24 kD proteins. CD61 is also a member of the integrin family known as gpIIIa or beta3 integrin. It is a 110 kD common beta subunit of CD51/CD61 or CD41/CD61 complex. CD51/CD61, also known as the vitronectin receptor, mediates the binding of platelets to immobilized vitronectin without prior activation. Other ligands include RGD-containing proteins such as fibrinogen, fibronectin, von Willebrand factor (vWf), laminin, thrombospondin and the neural adhesion molecule L1. CD51/CD61 also mediates cell-cell adhesion via interaction with CD31. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components.Synonyms: CD51, CD61, GP3A, GPIIIa, ITGAV, ITGB-3, ITGB3, Integrin alpha-V, Integrin beta-3, MSK8, Platelet membrane glycoprotein IIIa, VNRA, Vitronectin Receptor, Vitronectin receptor subunit alpha
Gene ID 9606
UniProt P06756
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 10 μL of 1/40-1/80 diluted antibody to label 10^6 cells in 100 μL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Simpson, Horton: "Expression of the vitronectin receptor during embryonic development; an immunohistological study of the ontogeny of the osteoclast in the rabbit." in: British journal of experimental pathology, Vol. 70, Issue 3, pp. 257-65, 1989 (PubMed).

Davies, Warwick, Totty et al.: "The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor." in: The Journal of cell biology, Vol. 109, Issue 4 Pt 1, pp. 1817-26, 1989 (PubMed).

Horton, Lewis, McNulty et al.: "Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens." in: Cancer research, Vol. 45, Issue 11 Pt 2, pp. 5663-9, 1985 (PubMed).

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