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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Bone Morphogenetic Protein 7 (BMP7) antibody
|Synonyms||OP-1, OP1, bmp7, fb83f09, wu:fb83f09, BMP-7, MGC68434, MGC68426, MGC130772, BMP7, Bmp7, zgc:153025|
Human, Mouse (Murine), Rat (Rattus)
Alternatives ELISA, Western Blotting (WB)
|4 references available|
|Quantity||0.1 mL (1.0 mg/ml) (Variants)|
|Price||396.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Immunogen||Recombinant human BMP7 (293-431 aa) purified from E. coli|
|Cross-Reactivity||Human, Mouse (Murine), Rat (Rattus)|
|Description||BMP-7 (bone morphogenetic protein-7), also known as OP-1 (osteogenic protein-1), is a member of the transforming growth factor b (TGF b ) superfamily. BMP-7 plays an essential role during ontogeny of the mammalian eye and kidney, also, is expressed in heart, lung, small intestine, limb bud and teeth. In addition, noggin, one of the soluble BMP antagonists, regulated the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition. Alternate Names: BMP-7, OP1, OP-1, Bone morphogenetic protein 7, Osteogenic protein 1, Eptotermin alfa (INN).|
|Application Notes||ELISA. Western blot (1/500 - 1/1,000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||PBS, pH 7.4, containing 0.09 % Sodium Azide|
|Storage||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.|
|Research Area||Organogenesis, Cell Cycle, Extracellular Matrix, Signaling, Hormones, Cytokines|
|Restrictions||For Research Use only|
Sampath, Coughlin, Whetstone et al.: "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 265, Issue 22, pp. 13198-205, 1990 (PubMed).
Godin, Takaesu, Robertson et al.: "Regulation of BMP7 expression during kidney development." in: Development (Cambridge, England), Vol. 125, Issue 17, pp. 3473-82, 1998 (PubMed).
Groppe, Greenwald, Wiater et al.: "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin." in: Nature, Vol. 420, Issue 6916, pp. 636-42, 2002 (PubMed).
Gregory, Ono, Charbonneau et al.: "The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix." in: The Journal of biological chemistry, Vol. 280, Issue 30, pp. 27970-80, 2005 (PubMed).