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Details for Product No. ABIN121890

Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (N-Term) antibody

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Antigen
Synonyms TX, ICH-2, Mih1/TX, ICEREL-II, ICE(rel)II, Casp11, Caspl, ich-3, CASP4
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN121890
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen A 16 amino acid peptide from human Caspase-4 amino terminus
Isotype IgG
Purification Affinity Chromatography
Alternative Name Caspase-4
Background Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller p20 and p10 subunits. The cellular localisation of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimers disease and Ischemia (1, 3) and confirms the involvement of Caspase-4 as an instigator of cellular apoptosis. Alternate Names: CASP4, EC=3.4.22.57, ICE, ICH2, ICH-2, TX, ICE-II, REL, ICE(rel)-II, Cysteine Protease ICErel-II.
UniProt P49662
Research Area Apoptosis/Necrosis
Application Notes Western Blot: 1.0ug/ml. Immunohistochemistry on paraffin sections: 2.0ug/ml, This product does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining, This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Spleen tissue. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Kamens, Paskind, Hugunin et al.: "Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 15250-6, 1995 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Hitomi, Katayama, Eguchi et al.: "Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death." in: The Journal of cell biology, Vol. 165, Issue 3, pp. 347-56, 2004 (PubMed).

Katayama, Imaizumi, Manabe et al.: "Induction of neuronal death by ER stress in Alzheimer's disease." in: Journal of chemical neuroanatomy, Vol. 28, Issue 1-2, pp. 67-78, 2004 (PubMed).

Alternatives for antigen "Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4)", type "Antibodies"
Hosts (112), (11), (9), (6), (6)
Reactivities (103), (60), (34), (12), (5), (2)
Applications (122), (47), (39), (30), (19), (11), (6), (5), (4), (3), (3), (1), (1)
Conjugates (8), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (24), (12), (8), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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