GNRHR antibody

Catalog No. ABIN122264

The Rabbit Polyclonal anti-GNRHR antibody is suitable to detect GNRHR in samples from Human, Mouse and Rat. It has been validated for IHC (p).

Quick Overview for GNRHR antibody (ABIN122264)

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNRHR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GNRHR Antibody

Specificity: Reacts with Gonadotropin-Releasing Hormone Receptor (GnRHR) (family: GPCR, subfamily: Releasing hormone).

Purification: Peptide Immunogen Affinity Chromatography.

Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 1-2 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for GNRHR

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Alternative Name: GnRH Receptor / GNRHR

Background: GnRHR is a Releasing-Hormone Receptor activated by gonadotropin-releasing hormone (GnRH). This receptor plays a major role in the regulation of reproductive functions. It modulates the synthesis and secretion of gonadotropin hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. In turn, LH and FSH regulate the release of steroid hormones from the gonads. Mutations in GnRHR have been linked to hypogonadotropic hypogonadism, a condition characterized by absence or delayed puberty and retarded bone maturation. GnRHR has been reported to be expressed mostly in the pituitary gonadotropes and in reproductive organs, including ovary, placenta, prostate, testis, and uterus. It is also expressed in breast, heart, kidney, liver, skeletal muscle, and thymus. No human ESTs have been isolated for this receptor.Synonyms: GRHR, GnRH-R, Gonadotropin-releasing hormone receptor

Gene ID: 2798

UniProt: P30968