BIN1 antibody

Catalog No. ABIN127306

This Rabbit Polyclonal antibody specifically detects BIN1 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for BIN1 antibody (ABIN127306)

Target: BIN1 (Bridging Integrator 1 (BIN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BIN1 Antibody

Specificity: The antibody recognizes ~65 kDa band of BIN-1. A cleavage fragment (~45 kDa) can also be detected in apoptotic samples.

Purification: Immunoaffinity

Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 578 of mouse BIN-1

Application Details

Application Notes: Western Blot: 0.5-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: PBS containing 0.1 % BSA, 30 % glycerol, and 0.01 % thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BIN1

Target: BIN1 (Bridging Integrator 1 (BIN1))

Alternative Name: BIN1 / AMPHL

Background: BIN-1 is a tumor suppressor protein that was identified in a genetic screen for proteins that interact with the MCY oncoprotein. BIN-1 inhibits the oncogenic activity of MYC, possibly through activating or facilitating apoptosis. BIN is a short-lived protein with a half-life of about 2 hours.Synonyms: Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, Myc box-dependent-interacting protein 1

Gene ID: 274

NCBI Accession: NP_004296

UniProt: O00499