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BCL2-Like 1 (BCL2L1) antibody
Alternatives Western Blotting (WB)
|4 references available|
|Price||236.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||KLH-conjugated peptide corresponding to amino acids 3-14 near the N-terminus mouse and human Bcl-xL1 Ig|
|Description||Mouse and human Bcl-xL (Mr 29 kDa) Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems.2 It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment.3 Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis4,5, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis.6-9 Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2.10-14 In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2,5,14 other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.16,|
|Synonyms||BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS, BCL-XL/S, DKFZp781P2092, BclX, Bcl2l, bcl-x, Bcl-XL, Bcl-Xs, Bcl(X)L, MGC99998, MGC113803, Bclx, bcl-X, Bcl-xl, BCL2L1, Bcl-xL, BCL-XL, bclx, xR11, bcl2l, bclxl, bcl-XL, bcl-xs, MGC69340, bcl-xl/s, bcl-xl, Bcl-xS|
|Application Notes||WORKING DILUTIONS Immunohistochemistry: Purified antibody 5-10 ug/mL Western Blotting:Purified antibody 1 ug/mL Since applications vary, you should determine the optimum working dilution of the product that is appropriate for your specific need.|
|Storage||The purified (UNLB) antibody is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added. Store at 2-8C. Reagent is stable for the period shown on the label if stored as directed.|
|Restrictions||For Research Use only|
Chittenden, Harrington, OConnor et al.: "Induction of apoptosis by the Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).
Kiefer, Brauer, Powers et al.: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).
Boise, González-García, Postema et al.: "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." in: Cell, Vol. 74, Issue 4, pp. 597-608, 1993 (PubMed).
Hsu, Wolter, Youle: "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3668-72, 1997 (PubMed).