T-Complex-Associated-Testis-Expressed 3 (TCTE3) (N-Term) antibody

Details for Product No. ABIN1450006
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Antigen
Synonyms D17Leh117c, LC2, Tcte-3, Tctex-2, Tctex-4, Tctex2, Tctex4, TCTEX1D3
Epitope
N-Term
(5), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(7), (4), (4)
Host
Rabbit
(5), (2)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(7), (5), (4), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN1450006
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Immunogen 19 amino acid synthetic peptide near the amino terminus of Human TCTEX1D3
Isotype IgG
Specificity This antibody is predicted not to cross-react with other members of the TCTEX-type family
Purification Affinity chromatography purified via peptide column
Alternative Name TCTE3
Background Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D3, also called TCTE3, has been identified as a gene responsible for congenital diaphragmatic hernia (CDH).
Alternate names: T-complex testis-specific protein 3, T-complex-associated testis-expressed protein 3, TCTEX1D3, Tcte-3, Tctex1 domain-containing protein 3
Gene ID 6991
NCBI Accession NP_777570
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Watanabe, Fujiwara, Shimizu et al.: "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q." in: Cytogenetics and cell genetics, Vol. 73, Issue 1-2, pp. 153-6, 1996 (PubMed).

He, Francis, Myers et al.: "Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments." in: The Journal of cell biology, Vol. 168, Issue 5, pp. 697-703, 2005 (PubMed).

Li, Lee, Cooper: "NudEL targets dynein to microtubule ends through LIS1." in: Nature cell biology, Vol. 7, Issue 7, pp. 686-90, 2005 (PubMed).

Chuang, Yeh, Bollati et al.: "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth." in: Developmental cell, Vol. 9, Issue 1, pp. 75-86, 2005 (PubMed).

Teshiba, Masumoto, Esumi et al.: "Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array." in: Pediatric surgery international, Vol. 27, Issue 2, pp. 193-8, 2011 (PubMed).

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