PIWIL2 antibody (Middle Region)

Catalog No. ABIN1450077

This anti-PIWIL2 antibody is a Rabbit Polyclonal antibody detecting PIWIL2 in WB and EIA. Suitable for Human and Mouse.

Quick Overview for PIWIL2 antibody (Middle Region) (ABIN1450077)

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIWIL2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PIWIL2 Antibody

Binding Specificity: Middle Region

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the center of Human PIWI-L2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PIWIL2

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Alternative Name: PIWIL2

Background: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.Synonyms: CT80, Cancer/testis antigen 80, HILI, Hiwi-like, Mili, Miwi-like, PIWIL1L, Piwi-like protein 2

Gene ID: 55124

NCBI Accession: NP_00129193

Pathways: Stem Cell Maintenance