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TEK Tyrosine Kinase, Endothelial (TEK) antibody (Biotin)

Details for Product No. ABIN155165
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Antigen
Synonyms TIE2, VMCM, TIE-2, VMCM1, CD202B, AA517024, Cd202b, Hyk, Tie2, tie-2, Tie-2, tie2, TEK, DKFZp469E064
Reactivity
Human
(177), (116), (72), (66), (66), (48), (48), (1), (1)
Host
Mouse
(128), (49), (23), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(18), (10), (8), (7), (5), (5), (5), (5), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Flow Cytometry (FACS)
(104), (100), (58), (54), (25), (19), (12), (10), (6), (5), (4), (4), (1), (1)
Pubmed 4 references available
Quantity 50 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN155165
445.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Recombinant human soluble CD202b / TIE-2 protein
Clone Cl-16
Isotype IgG1
Specificity The unconjugated monoclonal antibody will detect native human TIE-2 /TEK in ELISA experiments and on the surface of different human cell types.
Purification Protein G purified
Alternative Name CD202b / TEK
Background TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations, the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.
Alternate names: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK
Gene ID 7010
NCBI Accession NP_000450.2
UniProt Q02763
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Western Blot. ELISA. FACS analysis and cell sorting: 2 - 5 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore to a concentration of 0.1-1.0 mg/mL with sterile water. Centrifuge vial prior to opening
Buffer PBS, 50x BSA, 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for two weeks or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999 (PubMed).

Procopio, Pelavin, Lee et al.: "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30196-201, 1999 (PubMed).

Harris, Reusch, Barleon et al.: "Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 7, pp. 1992-7, 2001 (PubMed).

Van Hoof, Dormeyer, Braam et al.: "Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes." in: Journal of proteome research, Vol. 9, Issue 3, pp. 1610-8, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN155165
445.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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