CCR4 antibody

Catalog No. ABIN179723

The Mouse Monoclonal anti-CCR4 antibody is suitable to detect CCR4 in samples from Human. It has been validated for FACS and cELISA.

Quick Overview for CCR4 antibody (ABIN179723)

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCR4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Clone: KH-4F5

Product Details anti-CCR4 Antibody

Specificity: Anti-human CCR4

Purification: Protein G

Immunogen: immunisation with human CCR4 peptide

Isotype: IgG2a

Application Details

Application Notes: Flow cytometry: 1.2 µg/10^6 cells
Immunofluorescence: 1 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Comment:

Synonyms: CC chemokine receptor 4

Restrictions: For Research Use only

Handling

Concentration: 2 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

Target Details for CCR4

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Alternative Name: CCR4

Background: CCR4 (CC chemokine receptor 4) molecule belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane bound molecules composed of 7-transmembrane domains and coupled to G-proteins. CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells. It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways.

UniProt: P51679