TNFRSF4 antibody

Catalog No. ABIN180755

Product Details anti-TNFRSF4 Antibody

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Reactivity: Cat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF4 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: This antibody recognises feline CD134, otherwise known as OX40, a 43 kDa type I membrane protein and member of the tumor necrosis factor receptor superfamily.

Characteristics: Synonyms: OX40L receptor, ACT35 antigen, TXGP1L, Tumor necrosis factor receptor superfamilymember 4, TAX transcriptionally-activated glycoprotein 1 receptor

Purification: Affinity chromatography on Protein A.

Immunogen: CHO-derived feline CD134-Fc fusion protein. Spleen cells from immunised Balb/c micewere fused with cells of the NSO mouse myeloma cell line.

Clone: 7D6

Isotype: IgG1

Application Details

Application Notes: Flow Cytometery. Western Blot: 1.0 μg/mL, the antibody detects a band of approximately 43 kDa.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TNFRSF4

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Alternative Name: CD134 / TNFRSF4 (TNFRSF4 Products)

Background: This antigen is expressed predominantly by CD4+ activated T cells, and a key regulator of T cell-dependent immune responses. CD134 has been identified as the receptor for the OX40 ligand, CD252, expressed by activated B cells, acting as a co-stimulatory signal for the stimulation and secretion of immunoglobulins. CD134 has also been identified as a binding receptor for Feline Immunodeficiency Virus (FIV), acting along with CXC chemokine receptor 4 (CXCR4) to facilitate the entry of the virus into CD4+ primary target cells.Synonyms: ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, TNFRSF4, TXGP1L, Tumor necrosis factor receptor superfamily member 4

Gene ID: 790947

UniProt: A0S0B2

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints