Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4) antibody

Antigen: Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4)

Synonyms: PSMD4, MGC139713, xrpn10c, psmd4, MGC69347, im:6912672, wu:fc68c04, zgc:110247, Af1, Mcb1, angiocidin, ATMCB1, MBP1, MCB1, MULTIUBIQUITIN CHAIN BINDING PROTEIN, MULTIUBIQUITIN CHAIN BINDING PROTEIN 1, MULTIUBIQUITIN-CHAIN-BINDING PROTEIN 1, regulatory particle non-ATPase 10, RPN10, T9A14.7

Clonality: Polyclonal

Host: Rabbit

Reactivity: Cow (Bovine), Human, Rat (Rattus), Mouse (Murine), Pig (Porcine), Rabbit, Xenopus laevis

Application: Western Blotting (WB)

Catalog no.: ABIN182537

Additional Information

Alternative name: PSMD4 / MCB1

Gene ID: PSMD4

UniProt: P55036

Immunogen: The immunogen for anti-PSMD4 antibody: synthetic peptide directed towards the C terminal of human PSMD4

Sequence: VMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDG KKDKKEEDKK

Cross-Reactivity: Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)

Format: Lyophilized

Reconstitution: Add 50 µl of distilled water. Final anti-PSMD4 antibody concentration is 1 mg/ml.

Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid.

Characteristics: Antigen Size: 377 amino acids

Molecular Weight: 41kDa

Synonyms: PSMD4, MGC139713, xrpn10c, psmd4, MGC69347, im:6912672, wu:fc68c04, zgc:110247, Af1, Mcb1, angiocidin, ATMCB1, MBP1, MCB1, MULTIUBIQUITIN CHAIN BINDING PROTEIN, MULTIUBIQUITIN CHAIN BINDING PROTEIN 1, MULTIUBIQUITIN-CHAIN-BINDING PROTEIN 1, regulatory particle non-ATPase 10, RPN10, T9A14.7

Application Details

Application Notes: WB Suggested Anti-PSMD4 Antibody Titration: 0.2-1 ug/ml
Positive Control: Raji cell lysate.

Purification: Affinity Purified

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Restrictions: For Research Use only

Images

WB Suggested Anti-PSMD4 Antibody Titration: 0.2-1 ug/ml
Positive Control: Raji cell lysate

Publications

Product: Fujiwara, Tenno, Sugasawa et al.: "Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4760-7, 2004 (PubMed).