PSMD11 antibody (C-Term)

Catalog No. ABIN182724

The Rabbit Polyclonal anti-PSMD11 antibody (ABIN182724) specifically detects PSMD11 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Horse, Guinea Pig, Rabbit and Saccharomyces cerevisiae samples.

Quick Overview for PSMD11 antibody (C-Term) (ABIN182724)

Target: PSMD11 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 11 (PSMD11))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Horse, Guinea Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PSMD11 Antibody

Binding Specificity: C-Term

Sequence: ALRYAGRQTE ALKCVAQASK NRSLADFEKA LTDYRAELRD DPIISTHLAK

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PSMD11. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSMD11

Application Details

Application Notes: WB Suggested Anti-PSMD11 Antibody Titration: 5.0 µg/mL
Positive Control: Human brain.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 422 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMD11

Target: PSMD11 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 11 (PSMD11))

Alternative Name: PSMD11

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.
Alias Symbols: S9, Rpn6, p44.5
Protein Interaction Partner: HUWE1, SUMO2, SUMO3, PSMD14, UBC, MDM2, ASB11, SHFM1, PSMC2, PSMC1, RPS8, PSMD12, PSMD8, PSMD3, PSMD1, PSMC6, PSMC5, KCMF1, PRMT6, UCHL5, KIAA0368, ADRM1, RPS21, RPS15A, PARK2, RNF11, NOS2, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, FN1, CFTR, VCAM1, LRRK2, env,
Protein Size: 422

Molecular Weight: 47 kDa

Gene ID: 5717

NCBI Accession: NM_002815, NP_002806

UniProt: O00231

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway