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Serotonin Receptor 1A antibody (N-Term)

This Rabbit Polyclonal antibody specifically detects Serotonin Receptor 1A in WB. It exhibits reactivity toward Human and has been mentioned in 5+ publications.
Catalog No. ABIN184237

Quick Overview for Serotonin Receptor 1A antibody (N-Term) (ABIN184237)

Target

See all Serotonin Receptor 1A (HTR1A) Antibodies
Serotonin Receptor 1A (HTR1A)

Reactivity

  • 50
  • 31
  • 30
  • 1
  • 1
Human

Host

  • 43
  • 6
  • 2
Rabbit

Clonality

  • 46
  • 5
Polyclonal

Conjugate

  • 25
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Serotonin Receptor 1A antibody is un-conjugated

Application

  • 36
  • 17
  • 14
  • 13
  • 13
  • 7
  • 5
  • 4
  • 4
  • 4
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 15
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequence

    GQGNNTTSPP APFETGGNTT GISDVTVSYQ VITSLLLGTL IFCAVLGNAC

    Predicted Reactivity

    Human: 100%

    Characteristics

    This is a rabbit polyclonal antibody against HTR1A. It was validated on Western Blot using a cell lysate as a positive control.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human HTR1A
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator.

    Comment

    Antigen size: 422 AA

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Adeosun, Albert, Austin, Iyo: "17?-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells." in: Cellular and molecular neurobiology, Vol. 32, Issue 4, pp. 517-21, (2012) (PubMed).

    Szewczyk, Albert, Rogaeva, Fitzgibbon, May, Rajkowska, Miguel-Hidalgo, Stockmeier, Woolverton, Kyle, Wang, Austin: "Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 13, Issue 8, pp. 1089-101, (2010) (PubMed).

    Szewczyk, Albert, Burns, Czesak, Overholser, Jurjus, Meltzer, Konick, Dieter, Herbst, May, Rajkowska, Stockmeier, Austin: "Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 2, pp. 155-68, (2009) (PubMed).

    Cordeaux, Pasupathy, Bacon, Charnock-Jones, Smith: "Characterization of serotonin receptors in pregnant human myometrium." in: The Journal of pharmacology and experimental therapeutics, Vol. 328, Issue 3, pp. 682-91, (2009) (PubMed).

    Iyo, Kieran, Chandran, Albert, Wicks, Bissette, Austin: "Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress." in: Neuroscience, Vol. 163, Issue 4, pp. 1119-27, (2009) (PubMed).

  • Target

    Serotonin Receptor 1A (HTR1A)

    Alternative Name

    HTR1A

    Background

    This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity.
    Alias Symbols: 5HT1a, 5-HT1A, ADRBRL1, ADRB2RL1
    Protein Interaction Partner: UBC, RHOA, GABBR2, GPR26, S1PR1, S1PR3, HTR1D, HTR1B, GNAI3, HTR1A,
    Protein Size: 422

    Molecular Weight

    46 kDa

    Gene ID

    3350

    NCBI Accession

    NM_000524, NP_000515

    UniProt

    P08908

    Pathways

    JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour
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