Serotonin Receptor 1A antibody (N-Term)
Quick Overview for Serotonin Receptor 1A antibody (N-Term) (ABIN184237)
Target
See all Serotonin Receptor 1A (HTR1A) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- N-Term
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Sequence
- GQGNNTTSPP APFETGGNTT GISDVTVSYQ VITSLLLGTL IFCAVLGNAC
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Predicted Reactivity
- Human: 100%
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Characteristics
- This is a rabbit polyclonal antibody against HTR1A. It was validated on Western Blot using a cell lysate as a positive control.
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Purification
- Affinity Purified
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Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human HTR1A
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Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
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Comment
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Antigen size: 422 AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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17?-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells." in: Cellular and molecular neurobiology, Vol. 32, Issue 4, pp. 517-21, (2012) (PubMed).
: "Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 13, Issue 8, pp. 1089-101, (2010) (PubMed).
: "Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 2, pp. 155-68, (2009) (PubMed).
: "Characterization of serotonin receptors in pregnant human myometrium." in: The Journal of pharmacology and experimental therapeutics, Vol. 328, Issue 3, pp. 682-91, (2009) (PubMed).
: "Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress." in: Neuroscience, Vol. 163, Issue 4, pp. 1119-27, (2009) (PubMed).
: "
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17?-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells." in: Cellular and molecular neurobiology, Vol. 32, Issue 4, pp. 517-21, (2012) (PubMed).
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- Serotonin Receptor 1A (HTR1A)
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Alternative Name
- HTR1A
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Background
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This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity.
Alias Symbols: 5HT1a, 5-HT1A, ADRBRL1, ADRB2RL1
Protein Interaction Partner: UBC, RHOA, GABBR2, GPR26, S1PR1, S1PR3, HTR1D, HTR1B, GNAI3, HTR1A,
Protein Size: 422 -
Molecular Weight
- 46 kDa
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Gene ID
- 3350
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NCBI Accession
- NM_000524, NP_000515
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UniProt
- P08908
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Pathways
- JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour
Target
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