Cerebral Cavernous Malformation 2 (CCM2) antibody

Antigen: Cerebral Cavernous Malformation 2 (CCM2)

Synonyms: CCM2, OSM, C7orf22, MGC4067, MGC4607, PP10187, MGC74868, BC029157, MGC37115, RP23-169J19.3

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN185733

Additional Information

Alternative name: CCM2

Gene ID: 83605, 216527 (mouse)

Immunogen: C-KGEKSRDKKAHEK

Format: Affinity-purified

Description: All names and symbols: CCM2, cerebral cavernous malformation 2 , C7orf22, MGC4067, MGC4607, MGC74868, PP10187 . Official Symbol: CCM2. RefSeq number(s): NP_001025006.1, NP_113631.1

Specificity: This antibody is expected to recognize both reported isoforms (NP_001025006.1 and NP_113631.1). Human, Mouse, Rat, Dog 465 aa, 444 aa

Application Details

Application Notes: Peptide ELISA: antibody detection limit dilution 1:128,000. Western Blot: Approx 48kDa band observed in Human Heart lysates (calculated MW of 48.8kDa according to NP_113631.1). Recommended concentration: 0.03-0.1µg/ml.

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Buffer: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Storage: Aliquot and store at -20°C. Minimize freezing and thawing.

Research Area: Neurology

Restrictions: For Research Use only

Images

ABIN185733 (0.03µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Publications

Publications: Zawistowski, Stalheim, Uhlik et al.: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, 2005 (PubMed).