TRIM22 antibody (N-Term)

Catalog No. ABIN1881901

This Rabbit Polyclonal antibody specifically detects TRIM22 in WB. It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for TRIM22 antibody (N-Term) (ABIN1881901)

Target: TRIM22 (Tripartite Motif Containing 22 (TRIM22))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM22 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB33242

Product Details anti-TRIM22 Antibody

Binding Specificity: AA 67-96, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TRIM22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human TRIM22.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TRIM22 antibody (ABIN1881901)

Kajaste-Rudnitski, Pultrone, Marzetta, Ghezzi, Coradin, Vicenzi: "Restriction factors of retroviral replication: the example of Tripartite Motif (TRIM) protein 5 alpha and 22." in: Amino acids, Vol. 39, Issue 1, pp. 1-9, (2010) (PubMed).

Petersson, Lönnbro, Herr, Mörgelin, Gullberg, Drott: "The human IFN-inducible p53 target gene TRIM22 colocalizes with the centrosome independently of cell cycle phase." in: Experimental cell research, Vol. 316, Issue 4, pp. 568-79, (2010) (PubMed).

Ovsyannikova, Dhiman, Haralambieva, Vierkant, OByrne, Jacobson, Poland: "Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes." in: Human genetics, Vol. 127, Issue 2, pp. 207-21, (2010) (PubMed).

Ovsyannikova, Haralambieva, Dhiman, OByrne, Pankratz, Jacobson, Poland: "Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination." in: The Journal of infectious diseases, Vol. 201, Issue 2, pp. 207-13, (2009) (PubMed).

Gao, Duan, Xu, Xiong: "Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain." in: Hepatology (Baltimore, Md.), Vol. 50, Issue 2, pp. 424-33, (2009) (PubMed).

Target Details for TRIM22

Target: TRIM22 (Tripartite Motif Containing 22 (TRIM22))

Alternative Name: TRIM22

Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.

Molecular Weight: 56947

NCBI Accession: NP_001186502, NP_006065

UniProt: Q8IYM9