CDC7 antibody (N-Term)

Catalog No. ABIN1882165

This Rabbit Polyclonal antibody specifically detects CDC7 in WB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for CDC7 antibody (N-Term) (ABIN1882165)

Target: CDC7 (Cell Division Cycle 7 (CDC7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC7 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB3541

Product Details anti-CDC7 Antibody

Binding Specificity: AA 1-30, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CDC7 (CDC7L1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDC7 (CDC7L1).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CDC7 antibody (ABIN1882165)

Montagnoli, Bosotti, Villa, Rialland, Brotherton, Mercurio, Berthelsen, Santocanale: "Drf1, a novel regulatory subunit for human Cdc7 kinase." in: The EMBO journal, Vol. 21, Issue 12, pp. 3171-81, (2002) (PubMed).

Hess, Drong, Weiland, Slightom, Sclafani, Hollingsworth: "A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines." in: Gene, Vol. 211, Issue 1, pp. 133-40, (1998) (PubMed).

Jiang, Hunter: "Identification and characterization of a human protein kinase related to budding yeast Cdc7p." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 26, pp. 14320-5, (1998) (PubMed).

Target Details for CDC7

Target: CDC7 (Cell Division Cycle 7 (CDC7))

Alternative Name: CDC7 (CDC7L1)

Background: CDC7L1 is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors.

Molecular Weight: 63888

NCBI Accession: NP_001127891, NP_001127892, NP_003494

UniProt: O00311

Pathways: Mitotic G1-G1/S Phases, DNA Replication