Substance P antibody
| Antigen |
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| Synonyms |
NK2, NPK, NKNA, TAC2, Hs.2563, SP, NK1, NK-1, Nkna, PPT-A, MGC151458, 4930528L02Rik |
| Clonality |
Monoclonal (SP-DE4-21) |
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Host
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Reactivity
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Human (38), Rat (Rattus) (24), Mouse (Murine) (21), Guinea Pig (16), Rabbit (16), Cow (Bovine) (15), Horse (Equine) (15), Sheep (Ovine) (15), Chicken (1), Fish (1), Mammalian (1), Pig (Porcine) (1)
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Application
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 Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunofluorescence (IF)
Immunofluorescence (IF) (29), Flow Cytometry (FACS) (19), Immunohistochemistry (Frozen Sections) (IHC (fro)) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), ELISA (8), Immunohistochemistry (IHC) (8), Enzyme Immunoassay (EIA) (3), Western Blotting (WB) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Radioimmunoassay (RIA) (1)
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| Catalog no. |
ABIN192027 |
| Quantity |
10 µg (Variants) |
| Price |
195.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: Substance-P
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Gene ID
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6863
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Swiss-Prot
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P20366
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Immunogen
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Synthetic human Substance P. AA Sequence: R-P-R-P-Q-Q-F-F-G-L-M
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Cross-Reactivity
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Guinea Pig, Human, Mouse (Murine), Rat (Rattus)
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Isotype
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IgG1 (Matching secondary antibodies)
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Clone
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SP-DE4-21
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Description
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Substance P (SP) is currently thought to be one of the most important neurotransmittersand neurotransmitters in the brain. It is an undecapeptide belonging to the tachykininfamily, which consists of excitatory neuropeptides synthesised in neuronal and glial cellsof the human central and peripheral nervous system. Substance P, Neurokinin A,Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavageof the precursor Protachykinin-1. Substance P forms the major endogenous ligand forNeurokinin 1 Receptor. The pharmacology of Substance P has been associated with anumber of neurological and psychiatric disorders, namely nociception, migraine, asthma,nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. Ithas also been linked to obesity.
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Specificity
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The antibody reacts specifically with Substance P. No cross reaction against related Tachykinins (Neurokinin A, Neurokinin B, and Kassinin). Species: Human. Others not tested. Add. Information: LocusID 6863 (tachykinin precursor contains: substance K, substance P, neurokinin 1,neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
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Application Notes
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ELISA (1/10.000)Immunostaining (1/1000)Immunostaining of Rat Tissue (1/2000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Purification
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Purified
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Buffer
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0.1 M Glycin PBS pH 7,4Reconstitution: Restore in aqua bidest to 1 mg/ml.
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Storage
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Store the antibody lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
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Research Area
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Neurology, Cell/Tissue Markers
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Restrictions
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For Research Use only
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Alternatives for antigen "Substance P", type "Antibodies"
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Hosts
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Rabbit (37), Mouse (8), Guinea Pig (4), Rat (2)
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Reactivities
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Human (38), Rat (Rattus) (24), Mouse (Murine) (21), Guinea Pig (16), Rabbit (16), Cow (Bovine) (15), Horse (Equine) (15), Sheep (Ovine) (15), Chicken (1), Fish (1), Mammalian (1), Pig (Porcine) (1)
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Applications
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Immunofluorescence (IF) (29), Flow Cytometry (FACS) (19), Immunohistochemistry (Frozen Sections) (IHC (fro)) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), ELISA (8), Immunohistochemistry (IHC) (8), Enzyme Immunoassay (EIA) (3), Western Blotting (WB) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Radioimmunoassay (RIA) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitopes
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AA 4-11 (2)
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