phospholipid Scramblase 1 (PLSCR1) antibody

Antigen: phospholipid Scramblase 1 (PLSCR1)

Synonyms: MMTRA1B, Nor1, Tra1, Tra1a, Tra1b, Tras1, Tras2, MmTRA1a, MmTRA1b, MGC93252, PLSCR1, PLSCR2, MGC128844, mmtra1b, MGC84969, MGC148322

Clonality: Monoclonal (13A6 [TEC-23])

Host: Mouse

Reactivity: Rat (Rattus)

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)

Catalog no.: ABIN192390

Additional Information

Alternative name: PLSCR1 (rat)

Immunogen: BALB/c mice were immunized with pooled lipid rafts isolated from RBL-2H3 cells.Hybridoma cells were obtained after fusion of SP02 mouse myeloma cells with spleen cellsof immunized mice using standard procedures.

Format: Ascites

Isotype: IgG2a  (Matching secondary antibodies)

Clone: 13A6 [TEC-23]

Description: PLSCR1 (Phospholipid Scramblase 1) is a multiply palmitoylated endofacial plasmamembrane protein containing several SH3 and WW domain binding motives. In the plasmamembrane, PLSCR1 plays a role in transbilayer lipid redistributions and signal transduction.Nonpalmitoylated PLSCR1, however, is able to be transported into the nucleus and bindDNA. PLSCR1 potentiates the antiviral activity of interferon and its expression is highlyinduced by interferons and growth factors.

Specificity: The antibody 13A6 [TEC-23] binds to rat Phospholipid Scramblase 1 (PLSCR1), an 37-49kDa membrane-associated protein accelerating bidirectional movement of plasmamembrane phospholipids during conditions of elevated calcium.

Application Details

Buffer: Undiluted ascitic fuild with 15 mM sodium azide.

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Restrictions: For Research Use only

Images

Detection of PLSCR1 in rat basophilic leukemia (RBL) cell line lysate (A) and in PLSCR1 immunoprecipitate from RBL lysate (B). The antibody 13A6 (Tec-23) was used both for immunoprecipitation and immunodetection.