CD62L / L-Selectin antibody

Antigen: CD62L / L-Selectin

Clonality: Monoclonal (LT-TD180)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS)

Catalog no.: ABIN238440

Additional Information

Characteristics: Synonyms: SELL, LNHR, LYAM1, Leu-8, TQ1, gp90-MEL, LECAM1, LAM-1, Lymph node homing receptor,Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelialcell adhesion molecule 1, CD62 antigen-like family member L

Swiss-Prot: P14151

Immunogen: Peripheral blood leukocytes.

Cross-Reactivity: Human

Isotype: IgG1  (Matching secondary antibodies)

Clone: LT-TD180

Description: CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cellsurface of leukocytes and mediates their homing to inflammatory sites and peripherallymph nodes by enabling rolling along the venular wall. CD62L is also involved inactivation-induced neutrophil aggregation. Activation-dependent CD62L shedding,however, counteracts neutrophil rolling. CD62L has also signaling roles including enhanceof chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1(P-selectin glycoprotein ligand-1).

Specificity: The antibody LT-TD180 reacts with CD62L (L-selectin), a 74-95 kDa single chain type Iglycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes,monocytes and granulocytes, it is also present on a subset of NK cells and certainhematopoietic malignant cells. Species: HumanOthers not tested.

Application Details

Application Notes: Suitable for Flow Cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Purified

Buffer: PBS, pH 7.4 with 15 mM sodium azide as preservative.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only