CD24 antibody (PE)

Catalog No. ABIN238503

Product Details anti-CD24 Antibody (PE)

Target: CD24 (CD24 Molecule (CD24))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD24 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Characteristics: Synonyms: X62 heat stable antigen, HSA, Signal transducer CD24, Small cell lung carcinoma cluster 4antigen

Purification: Size-Exclusion Chromatography

Immunogen: Glycoproteins purified from human NALM-1 cell line.

Clone: SN3

Isotype: IgG1

Application Details

Application Notes: Suitable for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL ofwhole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade BSA (protease free)

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody in the dark at 2-8 °C. Do Not Freeze! . Avoid prolonged exposure to light.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for CD24

Target: CD24 (CD24 Molecule (CD24))

Alternative Name: CD24 (CD24 Products)

Synonyms: CD24A antibody, Cd24a antibody, CD24 molecule antibody, CD24 antibody, Cd24 antibody

Background: CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4, it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.Synonyms: HSA, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, X62 heat stable antigen

UniProt: P25063

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation