CD24 Molecule (CD24) antibody (PE)

Antigen: CD24 Molecule (CD24)

Synonyms: HSA, Cd24, Ly-52, nectadrin, CD24A, FLJ22950, FLJ43543, MGC75043

Clonality: Monoclonal (SN3)

Host: Mouse

Reactivity: Human

Conjugate: PE

Application: Flow Cytometry (FACS)

Catalog no.: ABIN238503

Additional Information

Characteristics: Synonyms: X62 heat stable antigen, HSA, Signal transducer CD24, Small cell lung carcinoma cluster 4antigen

Alternative name: CD24

Swiss-Prot: P25063

Immunogen: Glycoproteins purified from human NALM-1 cell line.

Cross-Reactivity: Human

Isotype: IgG1

Clone: SN3

Description: CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-likeGPI-anchored extracellular membrane glycoprotein expressed on several cell types,including B cells. When B cells are activated and induced to further maturation, however,CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, therebyregulating the activity of integrins and other proteins such as the chemokine receptorCXCR4, it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cellprecursors but not in mature resting B cells, where it instead inhibits their ability toproliferate in response to activation. CD24 expression is associated with invasiveness andpoorer prognosis of carcinomas and is a marker of exosomes secreted into urine andamniotic fluid.

Specificity: The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cellmalignancies. It is not expressed on human thymocytes. Species: HumanOthers not tested.

Application Details

Application Notes: Suitable for Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl ofwhole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Buffer: PBS containing 15 mM sodium azide and 0.2% (w/v) high-grade BSA(protease free) as stabilizer.Label: R-Phycoerythrin (PE)

Storage: Store the antibody in the dark at 2-8°C. Do Not Freeze! . Avoid prolonged exposure to light. Shelf life: One year from despatch.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only