TOLLIP antibody (C-Term)

Catalog No. ABIN265153

This Rabbit Polyclonal antibody specifically detects TOLLIP in WB and IHC (fro). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TOLLIP antibody (C-Term) (ABIN265153)

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOLLIP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TOLLIP Antibody

Binding Specificity: C-Term

Specificity: This antibody is specific for TOLLIP. Located in the cytoplasm and phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products (5).

Purification: Purified

Immunogen: A 16 amino acid peptide from near the carboxy terminus of human TOLLIP

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 μg/mL. Positive Control: Rat Brain Lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Alternative Name: TOLLIP

Background: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.Synonyms: Toll-interacting protein

Gene ID: 54472

NCBI Accession: NP_061882

UniProt: Q9H0E2