GRM8 antibody

Catalog No. ABIN265441

This Rabbit Polyclonal antibody specifically detects GRM8 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GRM8 antibody (ABIN265441)

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GRM8 Antibody

Specificity: This antibody detects endogenous levels of GluR8 protein. (region surrounding Gln871)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % pure SDS-PAGE

Application Details

Application Notes: ELISA: 1: 1 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GRM8

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Alternative Name: mGluR8 / GRM8

Background: GLuR-8 is a group III metabotropic glutamate receptor. In response to glutamate stimulation, GLuR-8 activates GTP-binding proteins that modulate second-messenger cascades. Alternative splicing of this integral membrane protein produces three isoforms: A, B, and C. Human GLuR-8 maps to q31.3-q32.1 of chromosome 7.Synonyms: GPRC1H, Metabotropic glutamate receptor 8

Molecular Weight: approx. 100 kDa

Gene ID: 2918

NCBI Accession: NP_000836

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane