BAX antibody (Alexa Fluor 488)
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- Target See all BAX Antibodies
- BAX (BCL2-Associated X Protein (BAX))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This BAX antibody is conjugated to Alexa Fluor 488
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Application
- Flow Cytometry (FACS)
- Purification
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- Clone
- 2D2
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product BAX Primary Antibody
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anti-BCL2-Associated X Protein (BAX) (AA 84-175) antibody
BAX Reactivity: Human, Mouse, Rat, Pig, Cow, Rabbit, Chicken, Zebrafish (Danio rerio) WB, ELISA, FACS, IP, IHC (p), IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-BCL2-Associated X Protein (BAX) (AA 1-100) antibodyBAX Reactivity: Human WB, IHC, IF, IP Host: Rabbit Polyclonal unconjugated
anti-BCL2-Associated X Protein (BAX) (AA 41-76) antibodyBAX Reactivity: Human, Mouse WB, FACS Host: Rabbit Polyclonal RB0952 unconjugated
anti-BCL2-Associated X Protein (BAX) (N-Term) antibodyBAX Reactivity: Human, Mouse, Rat, Monkey, Pig, Cow, Rabbit, Dog, Chicken, Sheep, Horse, Guinea Pig, Hamster, Goat, Avian, Cat, Donkey WB, IF Host: Goat Polyclonal unconjugated
anti-BCL2-Associated X Protein (BAX) (AA 1-158) antibodyBAX Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-BCL2-Associated X Protein (BAX) antibodyBAX Reactivity: Human ELISA, IHC, FACS Host: Mouse Monoclonal 2D8H2 unconjugated
anti-BCL2-Associated X Protein (BAX) (AA 13-160) antibodyBAX Reactivity: Human ELISA, IHC Host: Mouse Monoclonal 4H9B11 unconjugated
anti-BCL2-Associated X Protein (BAX) antibodyBAX Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 2G6B2 unconjugated
anti-BCL2-Associated X Protein (BAX) (AA 1-192) antibodyBAX Reactivity: Human WB, ELISA, IF, IHC (p), PLA Host: Mouse Monoclonal 1F5-1B7 unconjugated
anti-BCL2-Associated X Protein (BAX) (N-Term) antibodyBAX Reactivity: Human, Pig, Cow, Dog WB, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C
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- Target
- BAX (BCL2-Associated X Protein (BAX))
- Alternative Name
- Bax (BAX Products)
- Background
- Bax is a 21 kD pro-apoptotic protein known to regulate apoptosis. Bax is found in the cytoplasm, mitochondria, and nucleus and is highly expressed in hematopoietic stem cells, ovaries, and lymph nodes. Bax binds the anti-apoptotic protein Bcl-2 as a heterodimer or forms homodimers. The relative levels of pro-apoptotic proteins such as Bax and anti-apoptotic proteins such as Bcl-2 determines whether cell death will occur following an apoptotic stimulus. Bax accelerates the opening of mitochondrial VDAC altering membrane potential and allowing cytochrome c to pass out of the mitochondria into the cytosol to initiate downstream caspase activation. p53 can transcriptionally activate the Bax gene to induce apoptosis. Bax has been shown to be mutated in some human cancers.
- Pathways
- p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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