HVEM antibody (PE)

Catalog No. ABIN2663260

Product Details anti-HVEM Antibody (PE)

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Reactivity: Mouse

Host: Armenian Hamster

Clonality: Monoclonal

Conjugate: This HVEM antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: HMHV-1B18

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for HVEM

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Alternative Name: CD270 (TNFRSF14 Products)

Target Type: Viral Protein

Background: Herpes Virus Entry Mediator (HVEM, TR2) is a type I transmembrane protein of TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HAS) entry. Binding of HSV viral envelope glycoprotein D to this receptor has been shown to be part of the viral entry mechanism. It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs. The ligands of HVEM are LIGHT, BTLA, LTα, and CD160. HVEM activates NF-kB through the TNF-related cytokine LIGHT to serve as a costimulatory pathway during T cell activation. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160 to deliver a coinhibitory signal and limit inflammatory responses initiated by T cells. HVEM plays an important role in regulating lymphocyte activation and homeostasis in immune responses.

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints