HVEM antibody (Middle Region)

Catalog No. ABIN955275

The Rabbit Polyclonal anti-HVEM antibody (ABIN955275) specifically detects HVEM in WB, FACS, IHC (p) and EIA. The antibody is reactive with Human samples.

Quick Overview for HVEM antibody (Middle Region) (ABIN955275)

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HVEM antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-HVEM Antibody

Binding Specificity: AA 216-245, Middle Region

Specificity: This antibody detects TNFRSF14 / HVEM (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 216~245 amino acids from the Center region of human TNFRSF14

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for HVEM

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Alternative Name: TNFRSF14 / HVEM

Background: TNFRSF14 is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.Synonyms: HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2

Gene ID: 8764

NCBI Accession: NP_003811

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints