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- Target See all FOXP3 Antibodies
- FOXP3 (Forkhead Box P3 (FOXP3))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This FOXP3 antibody is conjugated to PE
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Application
- Flow Cytometry (FACS)
- Cross-Reactivity
- Cynomolgus, Rhesus Monkey, Baboon, Chimpanzee
- Purification
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Clone
- 259D
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product FOXP3 Primary Antibody
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anti-Forkhead Box P3 (FOXP3) (AA 190-412) antibody
FOXP3 Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (C-Term) antibodyVerified FOXP3 Reactivity: Mouse FACS, ELISA, IHC, IF Host: Goat Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 297-431) antibodyFOXP3 Reactivity: Human FACS, ELISA, IHC Host: Mouse Monoclonal 4F12A2 unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibodyFOXP3 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (C-Term) antibodyVerified FOXP3 Reactivity: Human WB, FACS, ELISA, IHC, IF, ICC Host: Goat Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (N-Term) antibodyFOXP3 Reactivity: Human, Mouse, Rat, Cow, Pig, Horse, Rabbit, Sheep, Dog, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibodyFOXP3 Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C1 unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 283-311), (C-Term) antibodyFOXP3 Reactivity: Human, Mouse WB, FACS, IHC (p) Host: Rabbit Polyclonal RB17111 unconjugated
anti-Forkhead Box P3 (FOXP3) antibody (APC)FOXP3 Reactivity: Human, Mouse FACS Host: Mouse Monoclonal 3G3 APC
anti-Forkhead Box P3 (FOXP3) (AA 1-431) antibodyFOXP3 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- FOXP3 (Forkhead Box P3 (FOXP3))
- Alternative Name
- FOXP3 (FOXP3 Products)
- Background
- FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence, the other (FOXP3 δ2) lacking exon 2. The 259D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235.
- Pathways
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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