CD180 antibody

Catalog No. ABIN2664307

Product Details anti-CD180 Antibody

Target: CD180 (CD180 Molecule (CD180))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD180 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Cross-Reactivity: Baboon, Cynomolgus, Rhesus Monkey

Purification: The antibody was purified by affinity chromatography.

Clone: MHR73-11

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD180

Target: CD180 (CD180 Molecule (CD180))

Alternative Name: CD180 (CD180 Products)

Background: CD180, also known as RP105, is a 105 kD member of the toll-like receptor (TLR) family and is expressed on most B cells, monocytes/macrophages and dendritic cells. The TLR family's structural characteristics are critically involved in protein-protein signaling interactions leading to the activation of the innate immune system. Additionally, MD-1, a secretory protein, associates with CD180 (RP105) at the cell surface and this complex, in conjunction with TLR4, recognizes bacterial LPS. The human CD180 (RP105) gene maps to 5q12. The MHR73-11 antibody is able to activate B cells and to protect against irradiation- or dexamethasone-induced apoptosis.

Pathways: Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades