MMP10 antibody

Catalog No. ABIN272036

The Rabbit Polyclonal anti-MMP10 antibody is suitable to detect MMP10 in samples from Human, Mouse and Rat. It has been validated for IF and IHC (p).

Quick Overview for MMP10 antibody (ABIN272036)

Target: MMP10 (Matrix Metallopeptidase 10 (Stromelysin 2) (MMP10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP10 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MMP10 Antibody

Specificity: This antibody detects endogenous levels of MMP-10 protein. (region surrounding Ile387)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MMP10

Target: MMP10 (Matrix Metallopeptidase 10 (Stromelysin 2) (MMP10))

Alternative Name: MMP-10

Background: Proteins of the matrix metalloproteinase (MMP) family are zinc containing proteolytic enzymes involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. They also play an important role in apoptosis, tumor cell growth, invasion, metastasis, as well as in angiogenesis and wound healing. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most of the MMP's contain a common domain structure, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. MMP10 degrades proteoglycans, gelatins of type I, III, IV, and V, weakly collagens III, IV, and V. and fibronectin. It activates procollagenase. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.Synonyms: MMP10, Matrix metalloproteinase-10, SL-2, STMY2, Stromelysin-2, Transin-2

Molecular Weight: approx. 54 kDa

Gene ID: 4319

NCBI Accession: NP_002416

UniProt: P09238