GP120 antibody

Catalog No. ABIN285511

This Goat Polyclonal antibody specifically detects GP120 in ELISA, WB and IHC. It exhibits reactivity toward Human Immunodeficiency Virus (HIV). It has been mentioned in 4+ publications

Quick Overview for GP120 antibody (ABIN285511)

Target: GP120 (HIV-1 gp120) (Human Immunodeficiency Virus 1 Surface Glycoprotein (HIV-1 gp120))

Reactivity: Human Immunodeficiency Virus (HIV)

Host: Goat

Clonality: Polyclonal

Conjugate: This GP120 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GP120 Antibody

Purification: purified

Purity: > 95 % pure

Immunogen: HIV1 gp120 antibody was raised in goat using purified native gp120 from strain IIIB as the immunogen.

Application Details

Application Notes: Optimal conditions should be determined byt he investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: Protein A purified IgG fraction in 10 mM PBS, pH 7.2 with 0.1 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

References for anti-GP120 antibody (ABIN285511)

Ikeda, Symeonides, Albin, Li, Thali, Harris: "HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G." in: PLoS pathogens, Vol. 14, Issue 4, pp. e1007010, (2018) (PubMed).

Usami, Wu, Göttlinger: "SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef." in: Nature, Vol. 526, Issue 7572, pp. 218-23, (2016) (PubMed).

Kondo, Melikyan: "Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells." in: PLoS ONE, Vol. 7, Issue 9, pp. e44827, (2013) (PubMed).

Miyauchi, Curran, Long, Kondo, Iwamoto, Engelman, Matsuda: "The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein." in: Retrovirology, Vol. 7, pp. 95, (2010) (PubMed).

Target Details for GP120

Target: GP120 (HIV-1 gp120) (Human Immunodeficiency Virus 1 Surface Glycoprotein (HIV-1 gp120))

Alternative Name: HIV1 Gp120

Target Type: Viral Protein

Background: Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120 kilodaltons. gp120 is essential for virus entry into cells as it plays a vital role in seeking out specific cell surface receptors for entry.