IL-17 antibody

Catalog No. ABIN293413

This Rabbit Polyclonal antibody specifically detects IL-17 in WB, ELISA and Func. It exhibits reactivity toward Human.

Quick Overview for IL-17 antibody (ABIN293413)

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Functional Studies (Func)

Product Details anti-IL-17 Antibody

Specificity: Recognizes human IL-17 (Interleukin-17/17A), a 32kD disulfide-linked homodimer consisting of two 136 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.

Purification: Purified

Immunogen: Recombinant human IL-17.

Type of Immunogen: Recombinant protein

Isotype: IgG

Application Details

Application Notes: Approved: ELISA (0.5 - 2 μg/mL), Func (0.93 - 1.3 μg/mL), WB (0.1 - 0.2 μg/mL)

Usage: ELISA: May be used in an indirect ELISA or as the capture reagent in a sandwich ELISA. Western Blot: May be used under either reducing or non-reducing conditions.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Distilled Water. For long term storage the addition of 0.09 % sodium azide is recommended. For functional studies do not add azide.

Concentration: Lot specific

Buffer: Lyophilized, PBS,  pH 7.4.

Target Details for IL-17

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Alternative Name: IL17

Background: Name/Gene ID: IL17

Synonyms: IL17