TNNI3 antibody

Catalog No. ABIN295183

This Goat Polyclonal antibody specifically detects TNNI3 in ELISA. It exhibits reactivity toward Human.

Quick Overview for TNNI3 antibody (ABIN295183)

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This TNNI3 antibody is un-conjugated

Application: ELISA

Product Details anti-TNNI3 Antibody

Specificity: Recognizes human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.

Purification: Affinity purified

Immunogen: Native human cardiac troponin I, purity greater than 98%.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for TNNI3

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Alternative Name: TNNI3 / CTnI

Background: Name/Gene ID: TNNI3

Synonyms: TNNI3, CTnI, CMD1FF, CMD2A, RCM1, Troponin I, cardiac, Troponin I, cardiac muscle, Troponin I type 3 (cardiac), Cardiac troponin I, CMH7

Gene ID: 7137

UniProt: P19429